Fibrosis is a pathological process caused by abnormal wound healing response, which
often leads to excessive deposition of extracellular matrix, distortion of organ architecture …

In the infarcted myocardium, cardiomyocyte necrosis triggers an intense inflammatory
reaction that not only is critical for cardiac repair, but also contributes to adverse remodeling …

Cardiovascular disease (CVD) is a class of diseases with high disability and mortality rates.
In the elderly population, the incidence of cardiovascular disease is increasing annually …

Cell therapy has been evaluated to enhance heart function after injury. Delivered cells
mostly act via paracrine mechanisms, including secreted growth factors, cytokines, and …

Acute myocardial infarction (MI) and ischemic heart disease are the leading causes of heart
failure and mortality. Currently, research on MI treatment is focused on angiogenic and anti …

Rationale: DPP-4 (dipeptidyl peptidase-4) inhibitors have increased the risk of heart failure
events in both randomized clinical trials and observational studies, but the mechanisms that …

Cardiac fibrosis is a heterogeneous disease, which is characterized by abundant
proliferation of interstitial collagen, disordered arrangement, collagen network …

Drugs that inhibit dipeptidyl peptidase-4 (DPP-4) are conventionally regarded as incretin-
based agents that signal through the glucagon-like peptide-1 (GLP-1) receptor. However …

Exosomes of different origins have been found to be protective against ischemic-induced
myocardial injury. This study examined the protective effects of circulating exosomes in the …

Aims The chemokine stromal derived factor-1α (SDF-1α) is known to protect the heart
acutely from ischaemia-reperfusion injury via its cognate receptor, CXCR4. However, the …