Viral infections are initiated by attachment of the virus to host cell surface receptors,
including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan …

Mapping non-canonical cellular pathways affected by approved medications can accelerate
drug repurposing efforts, which are crucial in situations with a global impact such as the …

Rotavirus assembly is a complex process that involves the stepwise acquisition of protein
layers in distinct intracellular locations to form the fully assembled particle. Understanding …

Rotavirus (RV) causes 200,000 deaths per year and imposes a serious burden to public
health and livestock farming worldwide. Currently, rehydration (oral and intravenous) …

Rotaviruses are the leading etiological agents of acute gastroenteritis in infants and young
children worldwide. These nonenveloped viruses enter cells using different types of …

Rotaviruses (RVs) are endemic in swine populations, and all swine herds certainly have a
history of RV infection and circulation. Rotavirus A (RVA) and C (RVC) are the most common …

A large number of viruses, including many human pathogens, bind cell-surface glycans
during the initial steps of infection. Viral glycan receptors such as glycosaminoglycans and …

A non-enveloped virus requires a membrane lesion to deliver its genome into a target cell.
For rotaviruses, membrane perforation is a principal function of the viral outer-layer protein …

Glycosphingolipids (GSLs) are a class of ceramide-based glycolipids essential for embryo
development in mammals. The synthesis of specific GSLs depends on the expression of …

Ceramide is a lipid messenger at the heart of sphingolipid metabolism. In concert with its
metabolizing enzymes, particularly sphingomyelinases, it has key roles in regulating the …