Bladder cancer, inflammageing and microbiomes

A Martin, BL Woolbright, S Umar, MA Ingersoll… - Nature Reviews …, 2022 - nature.com
Ageing is correlated with elevated bladder cancer incidence, morbidity and mortality.
Advanced age is also associated with elevated markers of chronic inflammation and …

The role of key gut microbial metabolites in the development and treatment of cancer

K Jaye, CG Li, D Chang, DJ Bhuyan - Gut Microbes, 2022 - Taylor & Francis
In recent years, the role of gut microbial metabolites on the inhibition and progression of
cancer has gained significant interest in anticancer research. It has been established that …

[HTML][HTML] The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation

DR Donohoe, LB Collins, A Wali, R Bigler, W Sun… - Molecular cell, 2012 - cell.com
Widespread changes in gene expression drive tumorigenesis, yet our knowledge of how
aberrant epigenomic and transcriptome profiles arise in cancer cells is poorly understood …

Histone deacetylases: unique players in shaping the epigenetic histone code

SAM Thiagalingam, KH CHENG, HJ Lee… - Annals of the New …, 2003 - Wiley Online Library
The epigenome is defined by DNA methylation patterns and the associated posttranslational
modifications of histones. This histone code determines the expression status of individual …

Impact of different types of diet on gut microbiota profiles and cancer prevention and treatment

RJ Klement, V Pazienza - Medicina, 2019 - mdpi.com
Diet is frequently considered as a food regimen focused on weight loss, while it is actually
the sum of food consumed by the organism. Western diets, modern lifestyle, sedentary …

Histone deacetylase inhibitors: an attractive therapeutic strategy against breast cancer

C Damaskos, S Valsami, M Kontos… - Anticancer …, 2017 - ar.iiarjournals.org
With a lifetime risk estimated to be one in eight in industrialized countries, breast cancer is
the most frequent type of cancer among women worldwide. Patients are often treated with …

Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells

MA Zimmerman, N Singh, PM Martin… - American Journal …, 2012 - journals.physiology.org
Butyrate, an intestinal microbiota metabolite of dietary fiber, has been shown to exhibit
protective effects toward inflammatory diseases such as ulcerative colitis (UC) and …

Effects of intestinal microbial–elaborated butyrate on oncogenic signaling pathways

J Chen, KN Zhao, L Vitetta - Nutrients, 2019 - mdpi.com
The intestinal microbiota is well known to have multiple benefits on human health, including
cancer prevention and treatment. The effects are partially mediated by microbiota-produced …

Sodium butyrate epigenetically modulates high‐fat diet‐induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome …

TM Henagan, B Stefanska, Z Fang… - British journal of …, 2015 - Wiley Online Library
Background and Purpose Sodium butyrate (NaB), an epigenetic modifier, is effective in
promoting insulin sensitivity. The specific genomic loci and mechanisms underlying …

Gut metabolites and breast cancer: the continuum of dysbiosis, breast cancer risk, and potential breast cancer therapy

K Jaye, D Chang, CG Li, DJ Bhuyan - International Journal of Molecular …, 2022 - mdpi.com
The complex association between the gut microbiome and cancer development has been
an emerging field of study in recent years. The gut microbiome plays a crucial role in the …