Role of ion channels and transporters in cell migration

A Schwab, A Fabian, PJ Hanley… - Physiological …, 2012 - journals.physiology.org
Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Na+/Ca2+ exchange and Na+/K+‐ATPase in the heart

MJ Shattock, M Ottolia, DM Bers… - The Journal of …, 2015 - Wiley Online Library
This paper is the third in a series of reviews published in this issue resulting from the
University of California Davis Cardiovascular Symposium 2014: Systems approach to …

Anticancer steroids: linking natural and semi-synthetic compounds

JAR Salvador, JFS Carvalho, MAC Neves… - Natural product …, 2013 - pubs.rsc.org
Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …

[HTML][HTML] Brain Na+, K+-ATPase activity in aging and disease

GR de Lores Arnaiz, MGL Ordieres - International journal of …, 2014 - ncbi.nlm.nih.gov
Na+/K+ pump or sodium-and potassium-activated adenosine 5'-triphosphatase (Na+, K+-
ATPase), its enzymatic version, is a crucial protein responsible for the electrochemical …

Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth

W Schoner, G Scheiner-Bobis - American Journal of …, 2007 - journals.physiology.org
Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in
mammals. Among them are the hydrophilic cardenolide ouabain and the more hydrophobic …

The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na, K-ATPase

JB Lingrel - Annual review of physiology, 2010 - annualreviews.org
The Na, K-ATPase is the membrane “pump” that generates the Na+ and K+ gradients across
the plasma membrane that drives many physiological processes. This enzyme is highly …

Protein interaction and Na/K-ATPase-mediated signal transduction

X Cui, Z Xie - Molecules, 2017 - mdpi.com
The Na/K-ATPase (NKA), or Na pump, is a member of the P-type ATPase superfamily. In
addition to pumping ions across cell membrane, it is engaged in assembly of multiple …

Binding of Src to Na+/K+-ATPase Forms a Functional Signaling Complex

J Tian, T Cai, Z Yuan, H Wang, L Liu… - Molecular biology of …, 2006 - Am Soc Cell Biol
We have shown that ouabain activates Src, resulting in subsequent tyrosine phosphorylation
of multiple effectors. Here, we tested if the Na+/K+-ATPase and Src can form a functional …

Cardiotonic steroids on the road to anti-cancer therapy

T Mijatovic, E Van Quaquebeke, B Delest… - … et Biophysica Acta (BBA …, 2007 - Elsevier
The sodium pump, Na+/K+-ATPase, could be an important target for the development of anti-
cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion …

Energy and dynamics of caveolae trafficking

C Matthaeus, JW Taraska - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in
adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane …