Adjuvants have been used in vaccines for over a century, however, the search for safe and
effective vaccine adjuvants continues. In recent decades toll-like-receptor (TLR) agonists …

Simple Summary Due to the broad functions of Toll-like receptor 2 (TLR2) in innate
immunity, the drive for the development of TLR2-targeted therapeutic treatments has …

Drug metabolism is generally associated with liver enzymes. However, in the case of
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), Mtb-mediated …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the most grievous
infectious diseases with long-term morbidity and unpredicted mortality rates globally. Thus …

During latency, DosR proteins of Mycobacterium tuberculosis (M. tb) get activated and help
the bacterium to remain dormant. We have shown earlier that 2 such proteins Rv2627c and …

Mycobacterium tuberculosis (Mtb) is an intracellular pathogen known to persist in host cells.
The apoptotic response of macrophages serves as a defense mechanism to inhibit the …

Mycobacterium tuberculosis is one of the major invasive intracellular pathogens causing
most deaths by a single infectious agent. The interaction between host immune cells and …

Tuberculosis, which is caused by Mycobacterium tuberculosis (Mtb), is among the most
pressing worldwide problems. Mtb uniquely interacts with innate immune cells through …

H37Ra is a virulence attenuated strain of Mycobacterium tuberculosis widely employed as a
model to investigate virulence mechanisms. Comparative high-throughput studies have …

Background: Tuberculosis (TB) is currently the second greatest killer worldwide and is
caused by a single infectious agent. Since Bacillus Calmette–Guérin (BCG) is the only …