MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …

Since their discovery 20 years ago, miRNAs have attracted much attention from all areas of
biology. These short (∼ 22 nt) non-coding RNA molecules are highly conserved in evolution …

Hydrocephalus, characterized by cerebral ventricular dilatation, is routinely attributed to
primary defects in cerebrospinal fluid (CSF) homeostasis. This fosters CSF shunting as the …

RNA-binding proteins (RBPs) have essential roles in RNA-mediated gene regulation, and
yet annotation of RBPs is limited mainly to those with known RNA-binding domains. To …

The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …

Reprogramming differentiated cells into induced pluripotent stem cells (iPSCs) promotes a
broad array of cellular changes. Here we show that the let-7 family of microRNAs acts as an …

Nearly every cell in the human body contains a set of programmable gene-silencing proteins
named Argonaute. Argonaute proteins mediate gene regulation by small RNAs and thereby …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Congenital hydrocephalus (CH), featuring markedly enlarged brain ventricles, is thought to
arise from failed cerebrospinal fluid (CSF) homeostasis and is treated with lifelong surgical …

Activation induces extensive changes in the gene expression program of naive CD4+ T
cells, promoting their differentiation into helper T cells that coordinate immune responses …