Pancreatic β-cell electrical activity and insulin secretion: of mice and men

P Rorsman, FM Ashcroft - Physiological reviews, 2018 - journals.physiology.org
The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Cardiometabolic risk in Canada: a detailed analysis and position paper by the cardiometabolic risk working group

LA Leiter, DH Fitchett, RE Gilbert, M Gupta… - Canadian Journal of …, 2011 - Elsevier
The concepts of “cardiometabolic risk,”“metabolic syndrome,” and “risk stratification” overlap
and relate to the atherogenic process and development of type 2 diabetes. There is …

Gut microbiota diversity and human diseases: should we reintroduce key predators in our ecosystem?

A Mosca, M Leclerc, JP Hugot - Frontiers in microbiology, 2016 - frontiersin.org
Most of the Human diseases affecting westernized countries are associated with dysbiosis
and loss of microbial diversity in the gut microbiota. The Western way of life, with a wide use …

Type 2 diabetes: demystifying the global epidemic

R Unnikrishnan, R Pradeepa, SR Joshi, V Mohan - Diabetes, 2017 - Am Diabetes Assoc
Type 2 diabetes (T2D) has attained the status of a global pandemic, spreading from affluent
industrialized nations to the emerging economies of Asia, Latin America, and Africa. There is …

[HTML][HTML] The biodiversity hypothesis and allergic disease: world allergy organization position statement

T Haahtela, S Holgate, R Pawankar, CA Akdis… - World Allergy …, 2013 - Elsevier
Biodiversity loss and climate change secondary to human activities are now being
associated with various adverse health effects. However, less attention is being paid to the …

Evidence-based clinical guidelines for immigrants and refugees

K Pottie, C Greenaway, J Feightner, V Welch… - Cmaj, 2011 - Can Med Assoc
Health: Deborah Assayag, Elizabeth Barnett, Jennifer Blake, Beverly Brockest, Giovani
Burgos, Glenn Campbell, Andrea Chambers, Angie Chan, Maryann Cheetham, Walter …

Inflammatory bowel disease in immigrants to Canada and their children: a population-based cohort study

EI Benchimol, DR Mack, A Guttmann… - Official journal of the …, 2015 - journals.lww.com
OBJECTIVES: The risk of inflammatory bowel disease (IBD) contributed by the environment
can be elucidated by assessing the risk in migrants from low prevalence to Western …

Deriving ethnic-specific BMI cutoff points for assessing diabetes risk

M Chiu, PC Austin, DG Manuel, BR Shah… - Diabetes care, 2011 - Am Diabetes Assoc
OBJECTIVE The definition of obesity (BMI≥ 30 kg/m2), a key risk factor of diabetes, is
widely used in white populations; however, its appropriateness in nonwhite populations has …

Natural immunity: biodiversity loss and inflammatory diseases are two global megatrends that might be related

L Von Hertzen, I Hanski, T Haahtela - EMBO reports, 2011 - embopress.org
Natural immunity: Biodiversity loss and inflammatory diseases are two global megatrends that
might be related: EMBO reports: Vol 12, No 11 Skip to Article Content Skip to Article Information …

Adipocyte hypertrophy, fatty liver and metabolic risk factors in South Asians: the Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE)

SS Anand, MA Tarnopolsky, S Rashid, KM Schulze… - PloS one, 2011 - journals.plos.org
Objective We sought to determine if differences in the distribution and characteristics of
adipose tissue between South Asians and white Caucasians account for differences in risk …