Neurofilament proteins, a major intermediate filament component of the neuronal
cytoskeleton, are organized as 10 nm thick filaments in axons and dendrites. They are large …

Neurofilaments are uniquely complex among classes of intermediate filaments in being
composed of four subunits (NFL, NFM, NFH and alpha-internexin in the CNS) that differ in …

Bone marrow stromal cells exhibit multiple traits of a stem cell population. They can be
greatly expanded in vitro and induced to differentiate into multiple mesenchymal cell types …

The activation of N-methyl-D-aspartate-receptors (NMDARs) in synapses provides plasticity
and cell survival signals, whereas NMDARs residing in the neuronal membrane outside …

A leading neurobiologist explores the fundamental function of dendritic spines in neural
circuits by analyzing different aspects of their biology, including structure, development …

Mechanisms underlying axonogenesis remain obscure. Although a large number of proteins
eventually become polarized to the axonal domain, in no case does protein …

It has been widely speculated that actin plays a central role in CNS synapse assembly, but
such a requirement for actin filaments (F-actin) has not yet been demonstrated …

NMDA receptors are excitatory neurotransmitter receptors critical for synaptic plasticity and
neuronal development in the mammalian brain. These receptors are found highly …

α-Internexin, a neuronal intermediate filament protein implicated in neurodegenerative
disease, coexists with the neurofilament (NF) triplet proteins (NF-L, NF-M, and NF-H) but has …

Mammalian neurofilament proteins, particularly midsized (NF-M) and heavy (NF-H)
molecular weight neurofilament proteins, are highly phosphorylated in axons. Neurofilament …