Recent advances in immunology and cancer research show that fatty acids, their
metabolism and their sensing have a crucial role in the biology of many different cell types …

Cancer is well recognized as a leading cause of mortality. Although surgery tends to be the
primary treatment option for many solid cancers, cancer surgery is still a risk factor for …

Ceramide kinase (CerK) is a lipid kinase that converts the proapoptotic ceramide to
ceramide 1-phosphate, which has been proposed to have pro-malignant properties and …

Arachidonic acid (AA) is a phospholipase A2 metabolite that has been reported to mediate a
plethora of cellular mechanisms involved in healthy and pathological states such as platelet …

The pre-metastatic niche is a favorable microenvironment for the colonization of metastatic
tumor cells in specific distant organs. Lipid droplets (LDs, also known as lipid bodies or …

NMR spectroscopy and matrix assisted laser desorption ionization mass spectrometry
imaging (MALDI MSI) are both commonly used to detect large numbers of metabolites and …

Background Cytosolic phospholipase A2alpha (cPLA2α), an enzyme that is responsible for
the hydrolysis of membrane phospholipids, is a key mediator of tumor transformation …

Müller glial cells, the major glial cell type in the retina, are activated by most retina injuries,
leading to an increased proliferation and migration that contributes to visual dysfunction. The …

Glioblastoma multiforme (GBM) is a life-threatening brain tumor. This study aimed to identify
potential targets of the long noncoding RNA (lncRNA) HULC that promoted the progression …

Cytosolic phospholipase A2α (cPLA2α) is the rate-limiting enzyme in releasing arachidonic
acid and biosynthesis of its derivative eicosanoids. Thus, the catalytic activity of cPLA2α …