Objectives To assess the efficacy of inhaled ciclesonide in reducing the risk of adverse
outcomes in COVID-19 outpatients at risk of developing severe illness. Methods …

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) created a global
pandemic (COVID-19) that has resulted in massive health and economic losses. The current …

Background For medical conditions with numerous interventions worthy of investigation,
there are many advantages of a multi-arm multi-stage (MAMS) platform trial approach …

Background: Although vaccines are currently available for coronavirus disease 2019
(COVID-19), there remains a need for an effective and affordable outpatient treatment for …

Background The emergency set-up and implementation of outpatient clinical trials on
epidemic emerging infectious diseases such as COVID-19 raise many issues in terms of …

The explanatory essays in The James Lind Library were written to promote wider
understanding of why fair tests of treatments are needed, and what they have come to …

Background: Over the past 30 years clinical trial registries have become a key institution
aiming to reduce bias and waste within global clinical research. Funders, journals, and …

Patient experiences and perspectives on trial participation and follow-up may influence their
compliance with research procedures or negatively impact their well-being. We aimed to …

Study Design Interventions such as medications are studied through a series of phased
trials (Table 1). Therapeutics are first introduced in humans after years of preliminary …

Assessing the efficacy of a new antiviral drug usually starts with in vitro studies, continues
with in vivo animal studies, and ends with studies in humans. Each of these three levels has …