The unique abilities of human pluripotent stem cells to self-renew and to differentiate into
cells of the three germ layers make them an invaluable tool for the future of regenerative …

Stem cells have been used in a clinical setting for many years. Haematopoietic stem cells
have been used for the treatment of both haematological and non-haematological disease; …

Simplified culture conditions are essential for large-scale drug screening and medical
applications of human pluripotent stem cells (hPSCs). However, hPSCs [ie, human …

Human induced pluripotent stem cells (hiPSCs) have the potential to differentiate virtually
into any cell type in unlimited quantities. Therefore, they are ideal for in vitro tissue modeling …

“Regenerative medicine” hopefully will provide novel therapies for diseases that remain
without effective therapy. This development is also true for most neurodegenerative …

Genomic integrity of human pluripotent stem cells (hPSCs) is essential for research and
clinical applications. However, genetic abnormalities can accumulate during hPSC …

The potential use of stem cells (SCs) for tissue engineering, regenerative medicine, disease
modeling, toxicological studies, drug delivery, and as in vitro model for the study of basic …

The field of regenerative medicine utilizes a wide array of technologies and techniques for
repairing and restoring function to damaged tissues. Among these, stem cells offer one of …

Abstract Embryonic Stem Cells (ESCs) are expected to show a stable euploid karyotype, but
in the last decade (sub) chromosomal aberrations have been systematically described in …

Genomic instability is recognized as one of the most important hurdles in the expanding field
of stem cell-based therapies. In the recent years, an accumulating body of evidence has …