Anti‐platelet therapy: cyclo‐oxygenase inhibition and the use of aspirin with particular regard to dual anti‐platelet therapy

TD Warner, S Nylander… - British journal of clinical …, 2011 - Wiley Online Library
Aspirin and P2Y12 antagonists are commonly used anti‐platelet agents. Aspirin produces its
effects through inhibition of thromboxane A2 (TXA2) production, while P2Y12 antagonists …

Pharmacology of P2Y receptors

I von Kügelgen - Brain research bulletin, 2019 - Elsevier
Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups …

Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists

AD Johnson, LR Yanek, MH Chen, N Faraday… - Nature …, 2010 - nature.com
Platelet function mediates both beneficial and harmful effects on human health, but few
genes are known to contribute to variability in this process. We tested association of 2.5 …

P2Y12 receptors in platelets and other hematopoietic and non-hematopoietic cells

C Gachet - Purinergic signalling, 2012 - Springer
The P2Y 12 receptor is a Gi-coupled ADP receptor first described in blood platelets where it
plays a central role in the complex processes of activation and aggregation. Platelet …

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation

L Stefanini, RC Roden… - Blood, The Journal of the …, 2009 - ashpublications.org
The importance of the second messengers calcium (Ca2+) and diacylglycerol (DAG) in
platelet signal transduction was established more than 30 years ago. Whereas protein …

Molecular mechanisms of platelet activation and aggregation induced by breast cancer cells

M Zarà, I Canobbio, C Visconte, J Canino, M Torti… - Cellular …, 2018 - Elsevier
Tumor cell-induced platelet aggregation represents a critical process both for successful
metastatic spread of the tumor and for the development of thrombotic complications in …

Proteome changes in platelets after pathogen inactivation—an interlaboratory consensus

M Prudent, A D'Alessandro, JP Cazenave… - Transfusion medicine …, 2014 - Elsevier
Pathogen inactivation (PI) of platelet concentrates (PCs) reduces the proliferation/replication
of a large range of bacteria, viruses, and parasites as well as residual leucocytes. Pathogen …

Inhibitory effect of caffeic acid on ADP-induced thrombus formation and platelet activation involves mitogen-activated protein kinases

Y Lu, Q Li, YY Liu, K Sun, JY Fan, CS Wang, JY Han - Scientific reports, 2015 - nature.com
Caffeic acid (CA), one of the active constituents of Radix Salvia miltiorrhiza e, exhibits
antioxidant and anti-inflammatory activities. However, few studies have assessed the ability …

Pharmacodynamic comparison of ticagrelor monotherapy versus ticagrelor and aspirin in patients after percutaneous coronary intervention: the TEMPLATE …

TW Johnson, S Baos, L Collett… - Journal of the …, 2020 - Am Heart Assoc
Background To assess differences in platelet inhibition during ticagrelor monotherapy (TIC)
or dual therapy with ticagrelor and aspirin (TIC+ ASP) in patients after percutaneous …

Antiplatelet agents affecting GPCR signaling implicated in tumor metastasis

G Rovati, A Contursi, A Bruno, S Tacconelli, P Ballerini… - Cells, 2022 - mdpi.com
Metastasis requires that cancer cells survive in the circulation, colonize distant organs, and
grow. Despite platelets being central contributors to hemostasis, leukocyte trafficking during …