In healthy individuals, plasma glucose concentration is tightly regulated by the action of the
hormones secreted by the endocrine pancreas, principally, insulin and glucagon. Insulin is …

The artificial pancreas is a long-awaited goal for the management of type 1 diabetes, and its
development was recently triggered by the development of continuous glucose sensors …

Glucose concentration in type 1 diabetes is a function of biological and environmental
factors which present high inter-patient variability. The objective of this study is to evaluate a …

The artificial pancreas aims at the automatic delivery of insulin for glycemic control in
patients with type 1 diabetes, ie, closed-loop glucose control. One of the challenges of the …

Type 1 diabetic patients need insulin therapy to keep their blood glucose close to normal. In
this paper an attempt is made to show how nonlinear control-oriented model may be used to …

Background: A promising approach to treat diabetes is the development of an automated
bihormonal pump administering glucagon and insulin. A physically and chemically stable …

Type 1 diabetes mellitus (T1DM) treatment depends on the delivery of exogenous insulin to
obtain near normal glucose levels. This article proposes a method for blood glucose level …

Non-invasive continuous glucose monitoring (NI-CGM) sensors are still at an early stage of
development, but, in the near future, they could become particularly appealing in diabetes …

Biological systems involving positive variables as concentrations are some examples of so-
called positive systems. This is the case of the glycemia–insulinemia system considered in …

In this article, two adaptive model predictive controllers (AMPC) are applied to regulate the
blood glucose in type 1 diabetic patients. The first controller is constructed based on a linear …