The endothelium layer lining the inner surface of blood vessels serves relevant
physiological functions in all body systems, including the exchanges between blood and …

Abstract Type-1 and type-3 interferons (IFNs) are important for control of viral replication;
however, less is known about the role of Type-2 IFN (IFNγ) in anti-viral immunity. We …

Viral co-infections have been implicated in worsening tuberculosis (TB) and during the
COVID-19 pandemic, the global rate of TB-related deaths has increased for the first time in …

Influenza A virus infection during pregnancy can cause adverse maternal and fetal
outcomes but the mechanism responsible remains elusive. Infection of outbred mice with …

SARS-CoV-2 infection during pregnancy is associated with severe COVID-19 and adverse
fetal outcomes, but the underlying mechanisms remain poorly understood. Moreover, clinical …

The dysregulated immune response and inflammation resulting in severe COVID-19 are still
incompletely understood. Having recently determined that aberrant death-ligand-induced …

Background Respiratory syncytial virus (RSV) infection in infants is a major cause of viral
bronchiolitis and hospitalisation. We have previously shown in a murine model that ongoing …

Since most genetically modified mice are C57BL/6 background, a mouse-adapted SARS-
CoV-2 that causes lethal infection in young C57BL/6 mice is useful for studying innate …

Summary Type I interferon (IFN-I) response is the first line of host defense against invading
viruses. In the absence of definite mouse models, the role of IFN-I in SARS-CoV-2 infection …

Introduction SARS-CoV-2, the cause of the COVID pandemic, is an RNA virus with a high
propensity to mutate. Successive virus variants, including variants of concern (VOC), have …