Metabolic tricks of cancer cells

K Hönigova, J Navratil, B Peltanova… - … et Biophysica Acta (BBA …, 2022 - Elsevier
One of the characteristics of cancer cells important for tumorigenesis is their metabolic
plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic …

Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond …

T Nemkov, JA Reisz, Y Xia, JC Zimring… - Expert review of …, 2018 - Taylor & Francis
Introduction: Recently, the classification of two 'novel'organs, the mesentere and interstitium,
was saluted as a scientific breakthrough and disseminated into mainstream media. The …

Acute cycling exercise induces changes in red blood cell deformability and membrane lipid remodeling

T Nemkov, SC Skinner, E Nader, D Stefanoni… - International journal of …, 2021 - mdpi.com
Here we describe the effects of a controlled, 30 min, high-intensity cycling test on blood
rheology and the metabolic profiles of red blood cells (RBCs) and plasma from well-trained …

CD147 promotes entry of pentamer-expressing human cytomegalovirus into epithelial and endothelial cells

AL Vanarsdall, SR Pritchard, TW Wisner, J Liu… - MBio, 2018 - Am Soc Microbiol
Human cytomegalovirus (HCMV) replicates in many diverse cell types in vivo, and entry into
different cells involves distinct entry mechanisms and different envelope glycoproteins …

Heteromeric solute carriers: function, structure, pathology and pharmacology

SJ Fairweather, N Shah, S Brӧer - Protein Reviews: Volume 21, 2021 - Springer
Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …

CD147: an integral and potential molecule to abrogate hallmarks of cancer

AMK Nyalali, AU Leonard, Y Xu, H Li, J Zhou… - Frontiers in …, 2023 - frontiersin.org
CD147 also known as EMMPRIN, basigin, and HAb18G, is a single-chain type I
transmembrane protein shown to be overexpressed in aggressive human cancers of CNS …

Structural insights on druggable hotspots in CD147: a bull's eye view

D Kumar, U Vetrivel, S Parameswaran… - Life sciences, 2019 - Elsevier
Abstract CD147/Basigin/EMMPRIN (Extracellular Matrix Metalloproteinase inducer) is a
single pass type1 transmembrane protein playing a central role in developmental process …

[HTML][HTML] Metabolic function and Therapeutic Potential of CD147 for Hematological Malignancies: an overview

I Spinello, C Labbaye, E Saulle - International Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Hematological malignancies refer to a heterogeneous group of neoplastic conditions of
lymphoid and hematopoietic tissues classified in leukemias, Hodgkin and non-Hodgkin …

Glucose and lactate transport in pancreatic cancer: glycolytic metabolism revisited

ME Cameron, A Yakovenko, JG Trevino - Journal of oncology, 2018 - Wiley Online Library
Membrane transporters fulfill essential roles in maintaining normal cellular function in health.
In cancer, transporters likewise facilitate the aberrant characteristics typical of proliferating …

A critical epitope in CD147 facilitates memory CD4+ T-cell hyper-activation in rheumatoid arthritis

N Guo, S Ye, K Zhang, X Yu, H Cui, X Yang… - Cellular & Molecular …, 2019 - nature.com
The abnormal activation of CD4+ CD45RO+ memory T (Tm) cells plays an important role in
the pathogenesis of rheumatoid arthritis (RA). Previous studies have shown that CD147 …