Development of sinomenine hydrochloride sustained-release pellet using a novel whirlwind fluidized bed

S Wu, Q Zeng, Z Zhang, X Zhang, Y Hou, Z Li… - Journal of Drug Delivery …, 2022 - Elsevier
The clinical application of Sinomenine hydrochloride (SH) oral solid formulation is limited
due to its short half-life and gastrointestinal side effects. The novel whirlwind fluidized bed …

Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets

SJ Loo, PWS Heng, LW Chan - International Journal of Pharmaceutics, 2022 - Elsevier
Micronized drug powders are generally unsuitable as tableting feed to produce minitablets
due to their cohesivity and poor flow. The silicification of fine paracetamol powder (PCM F) …

Cushioning pellets based on microcrystalline cellulose–Crospovidone blends for MUPS tableting

RN Elsergany, LW Chan, PWS Heng - International journal of …, 2020 - Elsevier
Compaction of multiple-unit pellet system (MUPS) tablets has been extensively reported to
be potentially challenging. Thus, there is a need for non-segregating cushioning agents to …

Fluidized bed processing: versatile technique in dosage form development

JJ Pansare, UN Pagar, RH Dode, PS Mogal… - 2022 - indianjournals.com
Fluidized bed processor is the popular and successful technique widely being in
pharmaceutical industries. Fluidized bed processor was developed in 1950. In this paper …

Experimental investigation and stochastic simulation of continuous spray agglomeration process in a horizontal fluidized bed

J Du - 2023 - repo.bibliothek.uni-halle.de
Spray fluidized bed agglomeration (SFBA) process is a size enlargement process widely
used in the chemical, pharmaceutical and food industry to change the physical properties of …

A Study on The Manufacturability of High Drug Load Minitablets

LS Jun - 2023 - search.proquest.com
The preparation of minitablets from feed powder with a high micronized drug load is
generally unattainable via direct compression due to its inherent cohesivity, high charging …

[引用][C] Dr Paul WS Heng, a Guru in Pharmaceutical Processing Research

TN Hiew - International journal of pharmaceutics, 2024 - iro.uiowa.edu