The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

In recent years views of eukaryotic gene expression have been transformed by the finding
that enormous diversity can be generated at the RNA level. Advances in technologies for …

Significant research efforts are ongoing to elucidate the complex molecular mechanisms
underlying amyotrophic lateral sclerosis (ALS), which may in turn pinpoint potential …

UV cross-linking and immunoprecipitation (CLIP) and individual-nucleotide resolution CLIP
(iCLIP) are methods to study protein-RNA interactions in untreated cells and tissues. Here …

We describe a comprehensive quantitative measure of the splicing impact of a complete set
of RNA 6-mer sequences by deep sequencing successfully spliced transcripts. All 4096 6 …

The regulation of alternative splicing involves interactions between RNA-binding proteins
and pre-mRNA positions close to the splice sites. T-cell intracellular antigen 1 (TIA1) and …

Most mammalian pre‐mRNA s are alternatively spliced in a manner that alters the resulting
open reading frame. Consequently, alternative pre‐mRNA splicing provides an important …

Glycogen synthase kinase-3 (GSK3) plays important roles in numerous signaling pathways
that regulate a variety of cellular processes including cell proliferation, differentiation …

Microbial enzymes have been used in a large number of fields, such as chemical,
agricultural and biopharmaceutical industries. The enzyme production rate and yield are the …

TIA1 and TIAL1 encode a family of U-rich element mRNA-binding proteins ubiquitously
expressed and conserved in metazoans. Using PAR-CLIP, we determined that both proteins …