Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Biological aging of human organ systems reflects the interplay of age, chronic disease,
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …

Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …

Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …

Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous
findings indicate that epigenetic age could be altered in viral infection. However, the …