Targeting multiple signaling pathways in cancer: The rutin therapeutic approach

Z Nouri, S Fakhri, K Nouri, CE Wallace, MH Farzaei… - Cancers, 2020 - mdpi.com
Multiple dysregulated signaling pathways are implicated in the pathogenesis of cancer. The
conventional therapies used in cancer prevention/treatment suffer from low efficacy …

The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives

AK Farha, RY Gan, HB Li, DT Wu… - Critical Reviews in …, 2022 - Taylor & Francis
Rutin is one of the most common dietary polyphenols found in vegetables, fruits, and other
plants. It is metabolized by the mammalian gut microbiota and absorbed from the intestines …

Preclinical evidence for the pharmacological actions of naringin: a review

S Bharti, N Rani, B Krishnamurthy, DS Arya - Planta medica, 2014 - thieme-connect.com
Naringin, chemically 4′, 5, 7-trihydroxyflavanone-7-rhamnoglucoside, is a major flavanone
glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. It has been …

Phytochemistry and bioactivity of Citrus flavonoids: a focus on antioxidant, anti-inflammatory, anticancer and cardiovascular protection activities

L Yi, S Ma, D Ren - Phytochemistry Reviews, 2017 - Springer
Epidemiological studies have suggested an inverse relationship between increased
consumption of fruits and reduced risk of chronic diseases, such as cardiovascular diseases …

Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1

CS Huang, YE Fan, CY Lin, ML Hu - The Journal of nutritional biochemistry, 2007 - Elsevier
The carotenoid lycopene has been associated with decreased risks of several types of
cancer, such as hepatoma. Although lycopene has been shown to inhibit metastasis, its …

Quercetin derivatives as potential therapeutic agents: an updated perspective on the treatment of nicotine-induced non-small cell lung cancer

NA Alsharairi - International Journal of Molecular Sciences, 2023 - mdpi.com
Flavonoids are the largest group of polyphenols, represented by many compounds that
exhibit high anticancer properties. Quercetin (Q) and its main derivatives (rutin, quercitrin …

[HTML][HTML] 1-Aminobenzotriazole: a mechanism-based cytochrome P450 inhibitor and probe of cytochrome P450 biology

PRO de Montellano - Medicinal chemistry, 2018 - ncbi.nlm.nih.gov
Aminobenzotriazole (1-ABT) is a pan-specific, mechanism-based inactivator of the
xenobiotic metabolizing forms of cytochrome P450 in animals, plants, insects, and …

Anthocyanin-rich haskap (Lonicera caerulea L.) berry extracts reduce nitrosamine-induced DNA damage in human normal lung epithelial cells in vitro

M Amararathna, DW Hoskin… - Food and chemical …, 2020 - Elsevier
Diets rich in polyphenols are known to reduce cancer among high-risk populations. Haskap
(Lonicera caerulea L.) berry has abundant phenolic acids and flavonoids, especially …

Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells

H Fukumura, M Sato, K Kezuka, I Sato, X Feng… - The Journal of …, 2012 - Springer
Cellular reactive oxygen species (ROS) production is increased by both temperature and
anticancer drugs. Antioxidants are known to suppress ROS production while cancer patients …

Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture

M Yano, M Ikeda, K Abe, H Dansako… - Antimicrobial agents …, 2007 - Am Soc Microbiol
To date, only a limited number of studies have reported finding an influence of ordinary
nutrients on hepatitis C virus (HCV) RNA replication. However, the effects of other nutrients …