Bone remodeling replaces old and damaged bone with new bone through a sequence of
cellular events occurring on the same surface without any change in bone shape. It was …

Introduction In bone tissue, bone resorption by osteoclasts and bone formation by
osteoblasts are repeated continuously. Osteoclasts are multinucleated cells that derive from …

In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …

Osteoclasts are bone-resorbing cells that are derived from hematopoietic precursor cells
and require macrophage-colony stimulating factor and receptor activator of nuclear factor-κB …

The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

The bone is an essential organ for locomotion and protection of the body, as well as
hematopoiesis and mineral homeostasis. In order to exert these functions throughout life …

Osteoclasts are unique cells that degrade the bone matrix. These large multinucleated cells
differentiate from the monocyte/macrophage lineage upon stimulation by two essential …

Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic
multinucleation process not only increases cell size but causes functional alterations …

Osteoclasts are cells derived from bone marrow macrophages and are important in
regulating bone resorption during bone homeostasis. Understanding what drives osteoclast …

The bony skeleton is maintained by local factors that regulate bone-forming osteoblasts and
bone-resorbing osteoclasts, in addition to hormonal activity. Osteoprotegerin protects bone …