• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Compared with the extensive data on left‐sided infective endocarditis (IE), there is much
less published information on the features and management of right‐sided IE. Right‐sided …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through March 1, 2020. Searches …

Aim This executive summary of the valvular heart disease guideline provides
recommendations for clinicians to diagnose and manage valvular heart disease as well as …

Background There has been an increase in the prevalence of drug abuse (DA) in the
national opioid epidemic. With increasing DA, there is an increased risk of infective …

Opioids are the most potent of all analgesics. Although traditionally used solely for acute self-
limited conditions and palliation of severe cancer-associated pain, a movement to promote …

The incidence of injection drug use–associated infective endocarditis has been increasing
rapidly over the last decade. Patients with drug use–associated infective endocarditis …

Background Across North America, the opioid overdose epidemic is leading to increasing
hospitalizations of people who use drugs (PWUD). However, hospitals are ill-prepared to …

The opioid overdose epidemic is one of the leading causes of death in adults. 1 Its
devastating effects have included not only a burgeoning overdose crisis but also multiple …

Fentanyl and its analogues have played an increasing role in opioid overdose deaths
across the country over the past decade. Such high-potency, non-prescription opioids are …