Fibronectin: molecular structure, fibrillar structure and mechanochemical signaling
The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of
cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate …
cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate …
Mechanochemistry of collagen
SM Siadat, JW Ruberti - Acta Biomaterialia, 2023 - Elsevier
The collagen molecular family is the result of nearly one billion years of evolution. It is a
unique family of proteins, the majority of which provide general mechanical support to …
unique family of proteins, the majority of which provide general mechanical support to …
Modulation of macrophages by in situ ligand bridging
Extracellular matrix (ECM) proteins containing cell‐attachable Arg‐Gly‐Asp (RGD)
sequences exhibit variable bridging and non‐bridging in fibronectin‐collagen and laminin …
sequences exhibit variable bridging and non‐bridging in fibronectin‐collagen and laminin …
Ligand coupling and decoupling modulates stem cell fate
In natural microenvironment, various proteins containing adhesive ligands in fibrous and
non‐fibrous structures dynamically couple and decouple to regulate stem cell fate. Herein …
non‐fibrous structures dynamically couple and decouple to regulate stem cell fate. Herein …
Extracellular matrix dynamics: a key regulator of cell migration across length-scales and systems
The interactions between cells and their surrounding extracellular matrix (ECM) are dynamic
and play critical roles in cell migration during development, health, and diseases. Recent …
and play critical roles in cell migration during development, health, and diseases. Recent …
Measuring collagen fibril diameter with differential interference contrast microscopy
SM Siadat, AA Silverman, CA DiMarzio… - Journal of structural …, 2021 - Elsevier
Collagen fibrils, linear arrangements of collagen monomers, 20–500 nm in diameter,
comprising hundreds of molecules in their cross-section, are the fundamental structural unit …
comprising hundreds of molecules in their cross-section, are the fundamental structural unit …
Tendon extracellular matrix assembly, maintenance and dysregulation throughout life
Abstract In his Lissner Award medal lecture in 2000, Stephen Cowin asked the
question:“How is a tissue built?” It is not a new question, but it remains as relevant today as it …
question:“How is a tissue built?” It is not a new question, but it remains as relevant today as it …
[HTML][HTML] The interactions between integrin α5β1 of liver cancer cells and fibronectin of fibroblasts promote tumor growth and angiogenesis
Z Peng, M Hao, H Tong, H Yang, B Huang… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) progression is closely related to pathological fibrosis,
which involves heterotypic intercellular interactions (HIIs) between liver cancer cells and …
which involves heterotypic intercellular interactions (HIIs) between liver cancer cells and …
Cell mediated remodeling of stiffness matched collagen and fibrin scaffolds
A Jagiełło, U Castillo, E Botvinick - Scientific reports, 2022 - nature.com
Cells are known to continuously remodel their local extracellular matrix (ECM) and in a
reciprocal way, they can also respond to mechanical and biochemical properties of their …
reciprocal way, they can also respond to mechanical and biochemical properties of their …
The matrix reloaded—the role of the extracellular matrix in cancer
Simple Summary During the development of solid cancers, the ECM undergoes significant
changes in composition and function that facilitate the growth and spread of cancer cells. To …
changes in composition and function that facilitate the growth and spread of cancer cells. To …