Hailey–Hailey disease is a rare blistering dermatosis first described in 1939 by the brothers
Howard and Hugh Hailey. Its incidence is estimated at 1/50,000. The inheritance is …

Abstract Calcium (Ca 2+) is a fundamental regulator of cell fate and intracellular Ca 2+
homeostasis is crucial for proper function of the nerve cells. Given the complexity of neurons …

The autosomal‐dominant genodermatoses Darier disease and Hailey‐Hailey disease
present special challenges to dermatologists. Despite their similar pathogenesis featuring …

Darier disease is a severe, rare autosomal dominant inherited skin condition caused by
mutations in the ATP2A2 gene encoding sarcoendoplasmic reticulum Ca2+-ATPase isoform …

The sarcoplasmic/endoplasmic reticulum Ca2+‐ATP ase 2a (SERCA 2a) performs active
reuptake of cytoplasmic Ca2+ and is a major regulator of cardiac muscle contractility …

Hailey–Hailey disease (HHD) is a rare autosomal dominant acantholytic dermatosis,
characterized by a chronic course of repeated and exacerbated skin lesions in friction …

Background Bone marrow-derived mesenchymal stem cells (BM-MSCs) have shown
therapeutic potential in various in vitro and in vivo studies in cutaneous wound healing …

Cell junctions integrate extracellular signals with intracellular responses to polarize tissues,
pattern organs, and maintain tissue architecture by promoting cell–cell adhesion and …

The Golgi apparatus is a membrane‐bound organelle that functions as a central role in the
secretory pathway. Since the discovery of the Golgi apparatus, its structure and function …

Mutation of the ATP2A2 gene encoding sarco-endoplasmic reticulum calcium ATPase 2
(SERCA2) was linked to Darier disease more than 2 decades ago; however, there remain …