Somatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that
exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its …

Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an
invaluable drug target for the pharmacological management of pituitary adenomas and …

Somatostatin (SST), an inhibitory polypeptide with two biologically active forms SST14 and
SST28, inhibits GH, prolactin (PRL), TSH, and ACTH secretion in the anterior pituitary gland …

G protein-coupled receptors (GPCRs) modulate every aspect of physiological functions
mainly through activating heterotrimeric G proteins. A majority of GPCRs promiscuously …

Most of the genetic variation associated with diabetes, through genome-wide association
studies, does not reside in protein-coding regions, making the identification of functional …

Background Brain activity governing cognition and behaviour depends on the fine-tuned
microenvironment provided by a tightly controlled blood–brain barrier (BBB). Brain …

Adipose-tissue (AT) is an endocrine organ that dynamically secretes multiple hormones, the
adipokines, which regulate key physiological processes. However, adipokines and their …

ABSTRACT Pituitary-hypothalamic-somatotropic (HPS) axis plays a key regulatory role in
the metabolic and physiological processes in mammals. It is considered that inflammatory …

Purpose Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) comprise a
heterogeneous group of malignancies often presenting with metastasis at diagnosis and …

Classic somatostatin analogues aimed at somatostatin receptor type 2, such as octreotide
and lanreotide, represent the mainstay of medical treatment for acromegaly. These agents …