Metabolic inflammation in obesity—At the crossroads between fatty acid and cholesterol metabolism

S Curley, J Gall, R Byrne… - Molecular Nutrition & …, 2021 - Wiley Online Library
Metabolic inflammation is a classic hallmark of obesity that is associated with numerous
cardiometabolic complications. Disturbances in fatty acid and cholesterol metabolism are …

mTOR in metabolic homeostasis and disease

X Liu, B Guo, Q Li, J Nie - Experimental Cell Research, 2024 - Elsevier
The ability to maintain cellular metabolic homeostasis is critical to life, in which mTOR plays
an important role. This kinase integrates upstream nutrient signals and performs essential …

[HTML][HTML] Use of human PBMC to analyse the impact of obesity on lipid metabolism and metabolic status: a proof-of-concept pilot study

A Costa, B Reynés, J Konieczna, M Martín, M Fiol… - Scientific reports, 2021 - nature.com
Peripheral blood mononuclear cells (PBMC) are widely used as a biomarker source in
nutrition/obesity studies because they reflect gene expression profiles of internal tissues. In …

[HTML][HTML] Obesity, metabolic health and omics: current status and future directions

M Paczkowska-Abdulsalam… - World Journal of …, 2021 - ncbi.nlm.nih.gov
The growing obesity epidemic is becoming a major public health concern, and the
associated costs represent a considerable burden on societies. Among the most common …

[HTML][HTML] An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABAA receptor

G Anagnostopoulos, O Motiño, S Li, V Carbonnier… - Cell death & …, 2022 - nature.com
Acyl-coenzyme-A-binding protein (ACBP), also known as a diazepam-binding inhibitor
(DBI), is a potent stimulator of appetite and lipogenesis. Bioinformatic analyses combined …

[HTML][HTML] Crossbred sows fed a western diet during pre-gestation, gestation, lactation, and post-lactation periods develop signs of lean metabolic syndrome that are …

R Lugarà, S Renner, E Wolf, A Liesegang… - Nutrients, 2022 - mdpi.com
Excessive dietary intake of fats and sugars (“Western diet”, WD) is one of the leading causes
of obesity. The consumption of the microalga Arthrospira platensis (spirulina, Sp) is …

A nine-hub-gene signature of metabolic syndrome identified using machine learning algorithms and integrated bioinformatics

G Liu, S Luo, Y Lei, J Wu, Z Huang, K Wang… - …, 2021 - Taylor & Francis
Early risk assessments and interventions for metabolic syndrome (MetS) are limited because
of a lack of effective biomarkers. In the present study, several candidate genes were …

Exploration of the mechanism of linoleic acid metabolism dysregulation in metabolic syndrome

Y Wen, Y Shang, Q Wang, V Ramachandran - Genetics Research, 2022 - cambridge.org
We aimed to explore the mechanism of the linoleic acid metabolism in metabolic syndrome
(MetS). RNA-seq data for 16 samples with or without MetS from the GSE145412 dataset …

[HTML][HTML] LncRNA functional annotation with improved false discovery rate achieved by disease associations

Y Wang, J Zhai, X Wu, EA Adu-Gyamfi, L Yang… - Computational and …, 2022 - Elsevier
The long non‐coding RNAs (lncRNAs) play critical roles in various biological processes and
are associated with many diseases. Functional annotation of lncRNAs in diseases attracts …

[HTML][HTML] Identification of novel genes whose expression in adipose tissue affects body fat mass and distribution: an RNA-Seq and Mendelian Randomization study

S Konigorski, J Janke, G Patone… - European Journal of …, 2022 - nature.com
Many studies have shown that abdominal adiposity is more strongly related to health risks
than peripheral adiposity. However, the underlying pathways are still poorly understood. In …