Fusion protein linkers: property, design and functionality

X Chen, JL Zaro, WC Shen - Advanced drug delivery reviews, 2013 - Elsevier
As an indispensable component of recombinant fusion proteins, linkers have shown
increasing importance in the construction of stable, bioactive fusion proteins. This review …

[HTML][HTML] DNA vaccines: History, molecular mechanisms and future perspectives

S Pagliari, B Dema, A Sanchez-Martinez… - Journal of Molecular …, 2023 - Elsevier
The history of DNA vaccine began as early as the 1960s with the discovery that naked DNA
can transfect mammalian cells in vivo. In 1992, the evidence that such transfection could …

Peptide-based vaccines for tuberculosis

W Gong, C Pan, P Cheng, J Wang, G Zhao… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. As a
result of the coronavirus disease 2019 (COVID-19) pandemic, the global TB mortality rate in …

Increasing the homogeneity, stability and activity of human serum albumin and interferon-α2b fusion protein by linker engineering

HL Zhao, XQ Yao, C Xue, Y Wang, XH Xiong… - Protein expression and …, 2008 - Elsevier
Previous studies in our laboratory have shown that when the N-terminus of interferon-α2b
(IFN-α2b) was directly fused of to the C-terminus of human serum albumin (HSA), the …

Cytokines and their role as immunotherapeutics and vaccine Adjuvants: The emerging concepts

T Rahman, A Das, MH Abir, IH Nafiz, AR Mahmud… - Cytokine, 2023 - Elsevier
Cytokines are a protein family comprising interleukins, lymphokines, chemokines,
monokines and interferons. They are significant constituents of the immune system, and they …

Adjuvant activity of cytokines

MG Tovey, C Lallemand - Vaccine Adjuvants: Methods and Protocols, 2010 - Springer
The activity of several potent adjuvants, including incomplete Freund's adjuvant, CpG
oligodeoxynucleotides, and alum, has been shown to be due at least in part to the induction …

Old and new vaccine approaches

R Arnon, T Ben-Yedidia - International immunopharmacology, 2003 - Elsevier
The conventional, currently available vaccines, though quite successful, suffer from a few
shortcomings which hamper future vaccine development. We present herewith some of the …

In vivo thrombin activity in the diatom Phaeodactylum tricornutum: biotechnological insights

A Messaabi, N Merindol, L Bohnenblust… - Applied Microbiology …, 2024 - Springer
Diatoms are responsible for 20% of global carbon dioxide fixation and have significant
potential in various biotechnological and industrial applications. Recently, the pennate …

[HTML][HTML] Plant-made immunotoxin building blocks: A roadmap for producing therapeutic antibody-toxin fusions

M Knödler, JF Buyel - Biotechnology Advances, 2021 - Elsevier
Molecular farming in plants is an emerging platform for the production of pharmaceutical
proteins, and host species such as tobacco are now becoming competitive with …

Enhancing the enzymatic hydrolysis efficiency of lignocellulose assisted by artificial fusion enzyme of swollenin-xylanase

L Du, X Cui, H Li, Y Wang, L Fan, R He, F Jiang… - Industrial Crops and …, 2021 - Elsevier
Low enzymatic hydrolysis efficiency prevents the economic biotechnological conversion of
lignocellulose to valuable products. To improve the lignocellulose degradation, artificial …