Recent advances in the synthesis, stability, and activation of platinum (IV) anticancer prodrugs
Platinum-based anticancer drugs have been widely applied in clinical settings for more than
40 years. The remarkable breakthroughs that have come from the use of these complexes in …
40 years. The remarkable breakthroughs that have come from the use of these complexes in …
Platinum iodido complexes: A comprehensive overview of anticancer activity and mechanisms of action
Platinum iodido complexes have long been recognized as synthetic intermediates of various
platinum complexes (eg, chlorido or carboxylato), including the world-wide used platinum …
platinum complexes (eg, chlorido or carboxylato), including the world-wide used platinum …
On the hydrolytic stability of unsymmetric platinum (iv) anticancer prodrugs containing axial halogens
The longstanding notion that Pt (IV) complexes are inert under physiological conditions
where there are limited reducing agents is facing a great challenge. Herein, we …
where there are limited reducing agents is facing a great challenge. Herein, we …
Cyclometallated platinum (IV) compounds as promising antitumour agents
M Crespo - Journal of Organometallic Chemistry, 2019 - Elsevier
abstract Since the discovery of the anticancer activity of cisplatin by Rosenberg, extensive
research has been carried out in order to develop new and more efficient platinum …
research has been carried out in order to develop new and more efficient platinum …
Synthesis, structure, and cytotoxicity of oxaliplatin-based platinum (IV) anticancer prodrugs bearing one axial fluoride
Fluorine plays more and more important roles in drug design and development. In recent
years, fluorine-containing organic drugs have already been applied in a broad range of …
years, fluorine-containing organic drugs have already been applied in a broad range of …
Investigations of the kinetics and mechanism of reduction of a carboplatin Pt (IV) prodrug by the major small-molecule reductants in human plasma
Y Liu, H Tian, L Xu, L Zhou, J Wang, B Xu… - International journal of …, 2019 - mdpi.com
The development of Pt (IV) anticancer prodrugs to overcome the detrimental side effects of
Pt (II)-based anticancer drugs is of current interest. The kinetics and reaction mechanisms of …
Pt (II)-based anticancer drugs is of current interest. The kinetics and reaction mechanisms of …
Ligand substitution reactions afford oxaliplatin-based platinum (IV) complexes bearing axial alkoxido ligands
The application of new synthetic methods in the area of platinum (IV) anticancer prodrugs
greatly increases the availability of accessible chemical entities that can be conjugated to …
greatly increases the availability of accessible chemical entities that can be conjugated to …
Three Reactions, One Catalyst: A Multi‐Purpose Platinum (IV) Complex and its Silica‐Supported Homologue for Environmentally Friendly Processes
Although platinum nanoparticles and complexes‐especially of Pt (0) and Pt (II)‐are well
known catalysts, siloxane‐based platinum complexes are rarely reported. Herein, a …
known catalysts, siloxane‐based platinum complexes are rarely reported. Herein, a …
Synthesis and characterisation of platinum (IV) polypyridyl complexes with halide axial ligands
BS McGhie, J Sakoff, J Gilbert, JR Aldrich-Wright - Inorganica Chimica Acta, 2019 - Elsevier
A series of complexes of the type [Pt (PL)(AL)(X) 2] 2+(where PL= 1, 10-phenanthroline, 5-
methyl-1, 10-phenanthroline or 5, 6-dimethyl-1, 10-phenanthroline; AL= 1S, 2S …
methyl-1, 10-phenanthroline or 5, 6-dimethyl-1, 10-phenanthroline; AL= 1S, 2S …
Pt (IV) Complexes with Biologically Active and Physicochemical Properties Modifier Ligands
The octahedral Pt (IV) complexes contain either inert or biologically active ligands where the
nature of these axial ligands provides additional stability and synergistic biological activity …
nature of these axial ligands provides additional stability and synergistic biological activity …