Walking the tightrope: proteostasis and neurodegenerative disease
A characteristic of many neurodegenerative diseases, including Alzheimer's disease (AD),
Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis …
Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis …
The ubiquitin-proteasome system in neurodegeneration
C McKinnon, SJ Tabrizi - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: Impairment of the ubiquitin-proteasome system (UPS) has been implicated in
the pathogenesis of a wide variety of neurodegenerative disorders, including Alzheimer's …
the pathogenesis of a wide variety of neurodegenerative disorders, including Alzheimer's …
DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson's disease
Dopamine dyshomeostasis has been acknowledged among the determinants of nigrostriatal
neuron degeneration in Parkinson's disease (PD). Several studies in experimental models …
neuron degeneration in Parkinson's disease (PD). Several studies in experimental models …
Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress
H Peng, J Yang, G Li, Q You, W Han, T Li, D Gao, X Xie… - Cell research, 2017 - nature.com
Alterations in cellular ubiquitin (Ub) homeostasis, known as Ub stress, feature and affect
cellular responses in multiple conditions, yet the underlying mechanisms are incompletely …
cellular responses in multiple conditions, yet the underlying mechanisms are incompletely …
Role of ubiquitin–proteasome and autophagy-lysosome pathways in α-synuclein aggregate clearance
Synuclein aggregation in neuronal cells is the primary underlying cause of
synucleinopathies. Changes in gene expression patterns, structural modifications, and …
synucleinopathies. Changes in gene expression patterns, structural modifications, and …
Neurodegeneration and Alzheimer's disease (AD). What can proteomics tell us about the Alzheimer's brain?
G Moya-Alvarado, N Gershoni-Emek, E Perlson… - Molecular & Cellular …, 2016 - ASBMB
Neurodegenerative diseases, such as Alzheimer′ s diseases (AD), are becoming more
prevalent as the population ages. However, the mechanisms that lead to synapse …
prevalent as the population ages. However, the mechanisms that lead to synapse …
The ubiquitin-proteasome system and learning-dependent synaptic plasticity–A 10 year update
Over 25 years ago, a seminal paper demonstrated that the ubiquitin-proteasome system
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …
Serum neurofilament light chain levels at attack predict post-attack disability worsening and are mitigated by inebilizumab: analysis of four potential biomarkers in …
O Aktas, HP Hartung, MA Smith, WA Rees… - Journal of Neurology …, 2023 - jnnp.bmj.com
Objective To investigate relationships between serum neurofilament light chain (sNfL),
ubiquitin C-terminal hydrolase L1 (sUCHL1), tau (sTau) and glial fibrillary acidic protein …
ubiquitin C-terminal hydrolase L1 (sUCHL1), tau (sTau) and glial fibrillary acidic protein …
The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration
Various neurodegenerative diseases are characterized by the accumulation of
amyloidogenic proteins such as tau, α‐synuclein, and amyloid‐β. Prior to the formation of …
amyloidogenic proteins such as tau, α‐synuclein, and amyloid‐β. Prior to the formation of …
Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome‐blocking complexes
Age‐dependent neurodegenerative diseases progressively form aggregates containing
both shared components (eg, TDP‐43, phosphorylated tau) and proteins specific to each …
both shared components (eg, TDP‐43, phosphorylated tau) and proteins specific to each …