The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

The thioredoxin system plays a key role in regulating the overall intracellular redox balance.
It basically comprises the small redox protein thioredoxin (Trx), nicotinamide adenine …

Stem cells have the capacity to differentiate into various lineages, and the ability to reliably
direct stem cell fate determination would have tremendous potential for basic research and …

Oxygen radicals regulate many physiological processes, such as signaling, proliferation,
and apoptosis, and thus play a pivotal role in pathophysiology and disease development …

Elevated lifetime estrogen exposure is a major risk factor for breast cancer. Recent
advances in the understanding of breast carcinogenesis clearly indicate that induction of …

Abstract Background 22q11. 2 deletion syndrome (22q11DS), a copy number variation
(CNV) disorder, occurs in approximately 1: 4000 live births due to a heterozygous …

Although gold compounds are now recognized as promising anticancer agents, so far only
gold (I) derivatives have been investigated for this purpose, whereas the use of gold (III) …

Despite significant treatment advances over the past decade, metastatic gastrointestinal
stromal tumor (GIST) remains largely incurable. Rare diseases, such as GIST, individually …

We previously reported that 17-β-estradiol (E2)-induced mitochondrial reactive oxygen
species (mtROS) act as signaling molecules. The purpose of this study was to investigate …

Mitocurcumin is a derivative of curcumin, which has been shown to selectively enter
mitochondria. Here we describe the anti-tumor efficacy of mitocurcumin in lung cancer cells …