Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well
as a predisposition to malignancies including leukemia and squamous cell carcinoma …

There are 15 different DNA polymerases encoded in mammalian genomes, which are
specialized for replication, repair or the tolerance of DNA damage. New evidence is …

DNA is continuously attacked by reactive species that can affect its structure and function
severely. Structural modifications to DNA mainly arise from modifications in its bases that …

Fanconi anemia is a human cancer predisposition syndrome caused by mutations in 13
Fanc genes. The disorder is characterized by genomic instability and cellular …

DNA interstrand cross-links (ICLs) are lesions caused by a variety of endogenous
metabolites, environmental exposures, and cancer chemotherapeutic agents that have two …

The maintenance of genome stability is critical for survival, and its failure is often associated
with tumorigenesis. The Fanconi anemia (FA) pathway is essential for the repair of DNA …

DNA interstrand crosslinks (ICLs) formed by antitumor agents, such as cisplatin or mitomycin
C, are highly cytotoxic DNA lesions. Their repair is believed to be triggered primarily by the …

Interstrand DNA crosslinks (ICLs) are the link between Watson-Crick strands of DNAs with
the covalent bond and prevent separation of DNA strands. Since the ICL lesion affects both …

Interstrand DNA crosslinks (ICLs) are formed by natural products of metabolism and by
chemotherapeutic reagents. Work in E. coli identified a two cycle repair scheme involving …