Nanoparticles are heterologous small composites that are usually between 1 and 100
nanometers in size. They are applied in many areas of medicine with one of them being …

Sustained delivery of analgesic agents at target sites remains a critical issue for effective
pain management. The use of nanocarriers has been reported to facilitate effective delivery …

Background Pain is a vital sense that indicates the risk of injury at a particular body part.
Successful control of pain is the principal aspect in medical treatment. In recent years, the …

Objective: The aim of the present study was to encapsulate vancomycin in different
liposomal formulations and compare the in vitro antimicrobial activity against …

Microtubes obtained from the self-assembly of l-diphenylalanine (FF-MTs) were evaluated
as potential vehicles for drug delivery. The biological marker Rhodamine B (RhB) was …

In this study, we reported the development and the physico-chemical characterization of
poloxamer 407 (PL407) and poloxamer 188 (PL188) binary systems as hydrogels for …

Numerous drug delivery systems have been applied to the problem of providing prolonged
duration local anesthesia (PDLA). Here we review the rationale for PDLA, the desirable …

From a clinical perspective, local anesthetics have rather widespread application in regional
blockade for surgery, postoperative analgesia, acute/chronic pain control, and even cancer …

Cyclodextrins are well-known macrocyclic oligosaccharides that consist of α-(1, 4) linked
glucose units and have been widely used as artificial enzymes, chiral separators, chemical …

Introduction: There is a clinical need for pharmaceutical dosage forms devised to prolong
the acting time of local anesthetic (LA) agents or to reduce their toxicity. Encapsulation of LA …