Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation
Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …
new era for disease modeling and drug discovery. Over the past decade, significant …
[HTML][HTML] In vitro modeling of the neurobiological effects of glucocorticoids: A review
K Bassil, AC Krontira, T Leroy, AIH Escoto… - Neurobiology of …, 2023 - Elsevier
Hypothalamic-pituitary adrenal (HPA) axis dysregulation has long been implicated in stress-
related disorders such as major depression and post-traumatic stress disorder …
related disorders such as major depression and post-traumatic stress disorder …
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …
Genetic liability to posttraumatic stress disorder symptoms and its association with cardiometabolic and respiratory outcomes
Importance Posttraumatic stress disorder (PTSD) has been reported to be a risk factor for
several physical and somatic symptoms. However, the genetics of PTSD and its potential …
several physical and somatic symptoms. However, the genetics of PTSD and its potential …
Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings
Major depressive disorder (MDD) is a complex and heterogeneous psychiatric syndrome
with genetic and environmental influences. In addition to neuroanatomical and circuit-level …
with genetic and environmental influences. In addition to neuroanatomical and circuit-level …
Single-nucleus transcriptome profiling of dorsolateral prefrontal cortex: mechanistic roles for neuronal gene expression, including the 17q21. 31 locus, in PTSD stress …
C Chatzinakos, CD Pernia… - American Journal of …, 2023 - Am Psychiatric Assoc
Objective: Multidisciplinary studies of posttraumatic stress disorder (PTSD) and major
depressive disorder (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease …
depressive disorder (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease …
Genotype× environment interactions in gene regulation and complex traits
C Boye, S Nirmalan, A Ranjbaran, F Luca - Nature Genetics, 2024 - nature.com
Genotype× environment interactions (GxE) have long been recognized as a key mechanism
underlying human phenotypic variation. Technological developments over the past 15 years …
underlying human phenotypic variation. Technological developments over the past 15 years …
The Psychedelic Future of Post-Traumatic Stress Disorder Treatment
TG Zaretsky, KM Jagodnik, R Barsic… - Current …, 2024 - ingentaconnect.com
Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following
exposure to a traumatic experience. An estimated 12 million US adults are presently affected …
exposure to a traumatic experience. An estimated 12 million US adults are presently affected …
Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders
Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …
CGG repeats in the human FMR1 gene regulate mRNA localization and cellular stress in developing neurons
CL Sirois, Y Guo, M Li, NE Wolkoff, T Korabelnikov… - Cell Reports, 2024 - cell.com
The human genome has many short tandem repeats, yet the normal functions of these
repeats are unclear. The 5′ untranslated region (UTR) of the fragile X messenger …
repeats are unclear. The 5′ untranslated region (UTR) of the fragile X messenger …