Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry

R Gupta, V Luxami, K Paul - Bioorganic chemistry, 2021 - Elsevier
Hydroxyquinoline (8-HQ) is a significant heterocyclic scaffold in organic and analytical
chemistry because of the properties of chromophore and is used to detect various metal ions …

Advances in thiosemicarbazone metal complexes as anti-lung cancer agents

XG Bai, Y Zheng, J Qi - Frontiers in Pharmacology, 2022 - frontiersin.org
The great success of cisplatin as a chemotherapeutic agent considerably increased
research efforts in inorganic biochemistry to identify more metallic drugs having the potential …

In vitro and in vivo anticancer activity of tridentate thiosemicarbazone copper complexes: Unravelling an unexplored pharmacological target

M Carcelli, M Tegoni, J Bartoli, C Marzano… - European Journal of …, 2020 - Elsevier
Certain metal complexes can have a great antitumor activity, as the use of cisplatin in
therapy has been demonstrating for the past fifty years. Copper complexes, in particular …

Mechanistic insights of chelator complexes with essential transition metals: antioxidant/pro-oxidant activity and applications in medicine

VA Timoshnikov, OY Selyutina, NE Polyakov… - International Journal of …, 2022 - mdpi.com
The antioxidant/pro-oxidant activity of drugs and dietary molecules and their role in the
maintenance of redox homeostasis, as well as the implications in health and different …

The coordination modes of (thio) semicarbazone copper (II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity

V Pósa, B Hajdu, G Tóth, O Dömötör, CR Kowol… - Journal of Inorganic …, 2022 - Elsevier
Thiosemicarbazones are promising candidates for anticancer therapy and their mechanism
of action is often linked to their metal chelating ability. In this study, five (thio) …

Pyridine-based NNS tridentate chitosan thiosemicarbazones and their copper (II) complexes: synthesis, characterization, and anticancer activity

HS Adhikari, A Garai, KD Manandhar, PN Yadav - ACS omega, 2022 - ACS Publications
Chitosan-functionalized pyridine-based thiosemicarbazones and their copper (II) complexes
have been found to own a substantial antiproliferative activity against the tumorigenic Madin …

New iron metabolic pathways and chelation targeting strategies affecting the treatment of all types and stages of cancer

GJ Kontoghiorghes - International Journal of Molecular Sciences, 2022 - mdpi.com
There is new and increasing evidence from in vitro, in vivo and clinical studies implicating
the pivotal role of iron and associated metabolic pathways in the initiation, progression and …

Synthesis, characterization, and anticancer activity of chitosan functionalized isatin based thiosemicarbazones, and their copper (II) complexes

HS Adhikari, A Garai, PN Yadav - Carbohydrate Research, 2023 - Elsevier
The one-pot synthetic method of condensation of isatin and 5-chloroisatin on to amino group
at C2 position of the pyranose ring chitosan in chitosan thiosemicarbazide was employed to …

Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety

A Mrozek-Wilczkiewicz, K Malarz, M Rejmund… - European Journal of …, 2019 - Elsevier
Thiosemicarbazones (TSC) are a subclass of iron-chelating agents that are believed to have
an anticancer activity. The high potential for the application of this compound class can be …

Nanoparticles of nucleotide-free analogue of vitamin B12 formed in protein nanocarriers and their neuroprotective activity in vivo

LA Maiorova, OA Gromova, IY Torshin… - Colloids and Surfaces B …, 2024 - Elsevier
Recently, we have described the first supermolecular nanoentities of vitamin B 12 derivative,
viz. monocyano form of heptabutyl cobyrinate, unique nanoparticles with strong noncovalent …