The overconsumption of highly caloric and palatable foods has caused a surge in obesity
rates in the past half century, thereby posing a healthcare challenge due to the array of …

The aorta is a blood vessel that provides a low-resistance path for blood flow directed from
the heart to peripheral organs and tissues. However, the aorta has another central …

Obstructive sleep apnea (OSA) is a common sleep disorder, effecting 17% of the total
population and 40–70% of the obese population (,). Multiple studies have identified OSA as …

Obstructive sleep apnea (OSA) is now recognized as an independent and important risk
factor for cardiovascular diseases such as hypertension, coronary heart disease, heart …

Objectives Intermittent hypoxia (IH), resulted from recurring episodes of upper airway
obstruction, is the hallmark feature and the most important pathophysiologic pathway of …

Background Obstructive sleep apnoea and the related intermittent hypoxia (IH) are widely
recognised as risk factors for incident cardiovascular diseases. Numerous studies support …

Background Obstructive sleep apnea (OSA) occurs in 2% of middle-aged women and 4% of
middle-aged men in the general population and the prevalence is much higher in specific …

Background Endothelial dysfunction and arterial stiffening play major roles in cardiovascular
diseases. The critical role for the miR-181 family in vascular inflammation has been …

Objective—One potential mechanism through which obesity exerts adverse effects on the
vascular system is by increasing aortic stiffness, a change known to be predictive of …

The advent of the obesity epidemic has highlighted the need to re-assess more closely the
pathophysiology of obesity-related hypertension with the aim of identifying new therapies. In …