Therapeutic evolution of benzimidazole derivatives in the last quinquennial period

W Akhtar, MF Khan, G Verma… - European journal of …, 2017 - Elsevier
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …

New progress in azole compounds as antimicrobial agents

HZ Zhang, LL Gan, H Wang… - Mini reviews in medicinal …, 2017 - ingentaconnect.com
The increasing incidence of microbial resistance and newly emerging pathogens have
become a serious challenge for public health. More and more efforts have been directed to …

Recent development of benzimidazole‐containing antibacterial agents

D Song, S Ma - ChemMedChem, 2016 - Wiley Online Library
Clinically significant antibiotic resistance is one of the greatest challenges of the twenty‐first
century. However, new antibacterial agents are currently being developed at a much slower …

Synthesis and investigation of novel benzimidazole derivatives as antifungal agents

NT Chandrika, SK Shrestha, HX Ngo… - Bioorganic & medicinal …, 2016 - Elsevier
The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal
strains have resulted in an increase in demand for new antifungal agents. Various …

Synthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents

FAS Alasmary, AM Snelling, ME Zain, AM Alafeefy… - Molecules, 2015 - mdpi.com
A library of 53 benzimidazole derivatives, with substituents at positions 1, 2 and 5, were
synthesized and screened against a series of reference strains of bacteria and fungi of …

A Review of Approaches to the Metallic and Non-Metallic Synthesis of Benzimidazole (BnZ) and Their Derivatives for Biological Efficacy

M Patel, G Avashthi, A Gacem, MS Alqahtani, HK Park… - Molecules, 2023 - mdpi.com
Heterocyclic compounds are significant lead drug candidates based on their various
structure–activity relationships (SAR), and their use in pharmaceutics is constantly …

Recent advancements on benzimidazole: A versatile scaffold in medicinal chemistry

ZMM Alzhrani, MM Alam… - Mini Reviews in Medicinal …, 2022 - ingentaconnect.com
Benzimidazole is a nitrogen-containing fused heterocycle which has been extensively
explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various …

Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ

K Haranahalli, S Tong, I Ojima - Bioorganic & medicinal chemistry, 2016 - Elsevier
With the emergence of multidrug-resistant bacterial strains, there is a dire need for new drug
targets for antibacterial drug discovery and development. Filamentous temperature sensitive …

Recent progress of bacterial FtsZ inhibitors with a focus on peptides

H Han, Z Wang, T Li, D Teng, R Mao, Y Hao… - The FEBS …, 2021 - Wiley Online Library
In recent years, the rise of antibiotic resistance has become a primary health problem. With
the emergence of bacterial resistance, the need to explore and develop novel antibacterial …

Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine

OO Ajani, DV Aderohunmu, CO Ikpo… - Archiv der …, 2016 - Wiley Online Library
Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of
biologically active compounds which are therapeutically useful agents in drug discovery and …