[HTML][HTML] Platinum-based neoadjuvant chemotherapy in triple-negative breast cancer: a systematic review and meta-analysis
Background The role of platinum-based neoadjuvant chemotherapy in triple-negative breast
cancer (TNBC) patients is highly controversial and it is not endorsed by current guidelines …
cancer (TNBC) patients is highly controversial and it is not endorsed by current guidelines …
DNA damaging agents and DNA repair: From carcinogenesis to cancer therapy
LC de Almeida, FA Calil, JA Machado-Neto… - Cancer Genetics, 2021 - Elsevier
Cancer genome instability arises from diverse defects in DNA-repair machinery, which make
cancer cells more susceptible to DNA targeting agents. The interrelation between DNA …
cancer cells more susceptible to DNA targeting agents. The interrelation between DNA …
[HTML][HTML] Machine learning-based identification of tumor-infiltrating immune cell-associated lncRNAs for improving outcomes and immunotherapy responses in patients …
Rationale: Accumulating evidence demonstrated that long noncoding RNAs (lncRNAs)
involved in the regulation of the immune system and displayed a cell-type-specific pattern in …
involved in the regulation of the immune system and displayed a cell-type-specific pattern in …
Machine learning-based tumor-infiltrating immune cell-associated lncRNAs for predicting prognosis and immunotherapy response in patients with glioblastoma
Long noncoding ribonucleic acids (RNAs; lncRNAs) have been associated with cancer
immunity regulation. However, the roles of immune cell-specific lncRNAs in glioblastoma …
immunity regulation. However, the roles of immune cell-specific lncRNAs in glioblastoma …
An artificial intelligence network‐guided signature for predicting outcome and immunotherapy response in lung adenocarcinoma patients based on 26 machine …
The immune cells play an increasingly vital role in influencing the proliferation, progression,
and metastasis of lung adenocarcinoma (LUAD) cells. However, the potential of immune …
and metastasis of lung adenocarcinoma (LUAD) cells. However, the potential of immune …
Bloom syndrome and the underlying causes of genetic instability
M Ababou - Molecular genetics and metabolism, 2021 - Elsevier
Autosomal hereditary recessive diseases characterized by genetic instability are often
associated with cancer predisposition. Bloom syndrome (BS), a rare genetic disorder, with< …
associated with cancer predisposition. Bloom syndrome (BS), a rare genetic disorder, with< …
Fight to the bitter end: DNA repair and aging
Y Chen, A Geng, W Zhang, Z Qian, X Wan… - Ageing Research …, 2020 - Elsevier
DNA carries the genetic information that directs complex biological processes; thus,
maintaining a stable genome is critical for individual growth and development and for …
maintaining a stable genome is critical for individual growth and development and for …
[HTML][HTML] DNA damage response and repair pathway alteration and its association with tumor mutation burden and platinum-based chemotherapy in SCLC
Introduction Impairment in DNA damage response and repair (DDR) pathway is known as a
predictive biomarker of platinum sensitivity. Recently, DDR alteration is re-emphasized as a …
predictive biomarker of platinum sensitivity. Recently, DDR alteration is re-emphasized as a …
BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant BRCA-mutant ovarian cancer
Poly (ADP-ribose) polymerase inhibitors (PARPis) have changed the treatment paradigm in
breast cancer gene (BRCA)–mutant high-grade serous ovarian carcinoma (HGSC) …
breast cancer gene (BRCA)–mutant high-grade serous ovarian carcinoma (HGSC) …
Precision oncology with drugs targeting the replication stress, ATR, and Schlafen 11
Simple Summary Chemotherapeutic DNA-damaging agents targeting replication are widely
used but predictive rationales for drug combinations and patient selection still need clinical …
used but predictive rationales for drug combinations and patient selection still need clinical …