Lipids, phospholipids and cholesterol in particular, are the predominant components of the
plasma membrane, wherein multidrug efflux transporters of the ATP-binding cassette (ABC) …

Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the
only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of …

Breast cancer is the most prevalent type of tumor and the second leading cause of death
due to cancer among women. Although screening methods, diagnosis and therapeutic …

Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …

Cisplatin and other platinum (II) analogs are widely used in clinical practice as anti-cancer
drugs for a wide range of tumors. The primary mechanism by which they exert their action is …

Cyclodextrins are cyclic oligosaccharides obtained by enzymatic digestion of starch. The α-,
β-and γ-cyclodextrins contain respectively 6, 7 and 8 glucopyranose units, with primary and …

Cisplatin is one of the most potent and widely used chemotherapeutic agent in the treatment
of several solid tumors, despite the high toxicity and the frequent relapse of patients due to …

Biomembranes constitute the first lines of defense of cells. While small molecules can often
permeate cell walls in bacteria and plants, they are generally unable to penetrate the barrier …

Matrix-assisted laser desorption ionisation imaging mass spectrometry (MALDI-MSI) is a
rapidly advancing technique for intact tissue analysis that allows simultaneous localisation …

Simple Summary Understanding the role of the plasma membrane in the responses of
cancer cells to chemotherapy is important because the cell membrane is directly involved in …