Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma

YT Chan, C Zhang, J Wu, P Lu, L Xu, H Yuan, Y Feng… - Molecular Cancer, 2024 - Springer
Liver cancer is a global health challenge, causing a significant social-economic burden.
Hepatocellular carcinoma (HCC) is the predominant type of primary liver cancer, which is …

[HTML][HTML] Biomarkers for the early diagnosis of hepatocellular carcinoma

N Tsuchiya, Y Sawada, I Endo, K Saito… - World journal of …, 2015 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading
cause of cancer-related deaths worldwide. Although the prognosis of patients with HCC is …

Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma

J Cai, L Chen, Z Zhang, X Zhang, X Lu, W Liu, G Shi… - Gut, 2019 - gut.bmj.com
Objective The lack of highly sensitive and specific diagnostic biomarkers is a major
contributor to the poor outcomes of patients with hepatocellular carcinoma (HCC). We …

The threshold of alpha-fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis

J Zhang, G Chen, P Zhang, J Zhang, X Li, D Gan… - PloS one, 2020 - journals.plos.org
Objective Hepatocellular carcinoma (HCC) has become a pressing health problem facing
the world today due to its high morbidity, high mortality, and late discovery. As a diagnostic …

GOLM1 exacerbates CD8+ T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages

J Chen, Z Lin, L Liu, R Zhang, Y Geng, M Fan… - … and Targeted Therapy, 2021 - nature.com
The immunosuppressive microenvironment plays an important role in tumor progression
and immunotherapy responses. Golgi membrane protein 1 (GOLM1) is correlated to …

[HTML][HTML] The role of N-glycosylation in cancer

Y Lin, DM Lubman - Acta Pharmaceutica Sinica B, 2024 - Elsevier
Despite advances in understanding the development and progression of cancer in recent
years, there remains a lack of comprehensive characterization of the cancer glycoproteome …

[HTML][HTML] Hepatocellular carcinoma: causes, mechanism of progression and biomarkers

AK Singh, R Kumar, AK Pandey - Current chemical genomics and …, 2018 - ncbi.nlm.nih.gov
Hepatocellular Carcinoma (HCC) is one of the most common malignant tumours in the
world. It is a heterogeneous group of a tumour that vary in risk factor and genetic and …

How viral genetic variants and genotypes influence disease and treatment outcome of chronic hepatitis B. Time for an individualised approach?

N Rajoriya, C Combet, F Zoulim, HLA Janssen - Journal of hepatology, 2017 - Elsevier
Chronic hepatitis B virus (HBV) infection remains a global problem. Several HBV genotypes
exist with different biology and geographical prevalence. Whilst the future aim of HBV …

Progress and prospects of biomarkers in primary liver cancer

YX Gao, TW Yang, JM Yin… - International …, 2020 - spandidos-publications.com
Tumor biomarkers are important in the early screening, diagnosis, therapeutic evaluation,
recurrence and prognosis prediction of tumors. Primary liver cancer is one of the most …

Presence of EpCAM‐positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma

K Schulze, C Gasch, K Staufer… - … journal of cancer, 2013 - Wiley Online Library
Current imaging technologies do not sufficiently detect micrometastasis and therefore do not
allow adequate stratification of patients with hepatocellular carcinoma (HCC) for curative or …