Podocytes maintain the glomerular filtration barrier, and the stability of this barrier depends
on their highly differentiated postmitotic phenotype, which also defines the particular …

The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

Chronic kidney disease (CKD) represents a leading cause of death in the United States.
There is no cure for this disease, with current treatment strategies relying on blood pressure …

Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

The progression of proteinuric kidney diseases is associated with podocyte loss, but the
mechanisms underlying this process remain unclear. Podocytes reenter the cell cycle to …

Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its
pathophysiological relevance and the mechanisms that compromise adaptive ER signalling …

Podocytes are specialized epithelial cells that cover the outer surfaces of glomerular
capillaries. Unique cell junctions, known as slit diaphragms, which feature nephrin and …

Background Diabetic kidney disease is associated with impaired podocyte autophagy and
subsequent podocyte injury. The regulation of podocyte autophagy is unique because it …