Advances in HDL: much more than lipid transporters

S Ben-Aicha, L Badimon, G Vilahur - International Journal of Molecular …, 2020 - mdpi.com
High Density Lipoprotein (HDL) particles, beyond serving as lipid transporters and playing a
key role in reverse cholesterol transport, carry a highly variable number of proteins, micro …

Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European …

J Tunon, L Badimon, ML Bochaton-Piallat… - Cardiovascular …, 2019 - academic.oup.com
Dysregulated lipid metabolism induces an inflammatory and immune response leading to
atherosclerosis. Conversely, inflammation may alter lipid metabolism. Recent treatment …

Hyperlipidaemia and cardioprotection: Animal models for translational studies

I Andreadou, R Schulz, L Badimon… - British journal of …, 2020 - Wiley Online Library
Hyperlipidaemia is a well‐established risk factor for cardiovascular diseases and therefore,
many animal model have been developed to mimic the human abnormal elevation of blood …

Pharmacological intervention to modulate HDL: what do we target?

NJ Woudberg, S Pedretti, S Lecour, R Schulz… - Frontiers in …, 2018 - frontiersin.org
The cholesterol concentrations of low-density lipoprotein (LDL) and high-density lipoprotein
(HDL) have traditionally served as risk factors for cardiovascular disease. As such, novel …

Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans

T Padro, V Santisteban, P Huedo… - Cardiovascular …, 2024 - academic.oup.com
Aims Probiotics with high bile salt hydrolase (BSH) activity have shown to promote
cardiovascular health. However, their mechanism (s) of action remain poorly understood …

Moderate beer intake and cardiovascular health in overweight individuals

T Padro, N Muñoz-García, G Vilahur, P Chagas… - Nutrients, 2018 - mdpi.com
Consistent epidemiological evidence indicates that low-to-moderate alcohol consumption is
inversely associated with cardiovascular event presentation, while high levels of alcohol …

Bile acid sequestrants for hypercholesterolemia treatment using sustainable biopolymers: Recent advances and future perspectives

MS Islam, A Sharif, N Kwan, KC Tam - Molecular pharmaceutics, 2022 - ACS Publications
Bile acids, the endogenous steroid nucleus containing signaling molecules, are responsible
for the regulation of multiple metabolic processes, including lipoprotein and glucose …

HDL maturation and remodelling

KL Ong, BJ Cochran, B Manandhar, S Thomas… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Cholesterol in the circulation is mostly transported in an esterified form as a component of
lipoproteins. The majority of these cholesteryl esters are produced in nascent, discoidal high …

[HTML][HTML] HDL subclass proteomic analysis and functional implication of protein dynamic change during HDL maturation

Y Zhang, SM Gordon, H Xi, S Choi, MA Paz, R Sun… - Redox biology, 2019 - Elsevier
Recent clinical trials reported that increasing high-density lipoprotein-cholesterol (HDL-C)
levels does not improve cardiovascular outcomes. We hypothesize that HDL proteome …

Recombinant LCAT (lecithin: cholesterol acyltransferase) rescues defective HDL (high-density lipoprotein)-mediated endothelial protection in acute coronary …

A Ossoli, S Simonelli, M Varrenti, N Morici… - … and Vascular Biology, 2019 - Am Heart Assoc
Objective—Aim of this study was to evaluate changes in LCAT (lecithin: cholesterol
acyltransferase) concentration and activity in patients with an acute coronary syndrome, to …