Classical microbiology techniques are relatively slow in comparison to other analytical
techniques, in many cases due to the need to culture the microorganisms. Furthermore …

Publisher Summary This chapter attempts to identify the principles and issues elucidated in
animal models that may provide insights for the development of effective approaches to …

Oncolytic herpes simplex virus type 1 (HSV-1) vectors are promising therapeutic agents for
cancer. Their efficacy depends on the extent of both intratumoral viral replication and …

The immediate early protein ICP47 of herpes simplex virus (HSV) inhibits the transporter for
antigen processing (TAP)‐mediated translocation of antigen‐derived peptides across the …

Reduction of major histocompatibility complex class I cell surface expression occurs in
adenovirus-, herpes simplex virus-, human cytomegalovirus (HCMV)-, and murine …

The cotton rat Sigmodon hispidus has provided an animal model of adenovirus pneumonia
that permits investigation of the viral gene products required to produce the disease and the …

The requirement for interferon-γ (IFNγ) in resolution of an HSV-2 vaginal infection and the
cellular sources of this cytokine in the vaginal mucosa were assessed. IFNγ levels in vaginal …

For decades cell biologists have relied on viruses to facilitate the study of complex cellular
function. More recently, the tragedy of the AIDS epidemic has focused considerable human …

Cells infected with herpes simplex virus type 1 (HSV-1), but not HSV-2, express on their
surfaces a receptor for the complement component C3b. Receptor activity is markedly …

Viral persistence depends on the successful avoidance of the host's immunologic
surveillance system. This review, which focuses specifically on the herpesviruses …