The journey of boswellic acids from synthesis to pharmacological activities

EA Ragab, MF Abd El-Wahab, AS Doghish… - Naunyn-schmiedeberg's …, 2024 - Springer
There has been a lot of interest in using naturally occurring substances to treat a wide
variety of chronic disorders in recent years. From the gum resin of Boswellia serrata and …

Targeting the Nrf2 signaling pathway using phytochemical ingredients: A novel therapeutic road map to combat neurodegenerative diseases

X Bai, Z Bian, M Zhang - Phytomedicine, 2023 - Elsevier
Background Nuclear factor erythroid 2-related factor 2 (Nrf2) is a classical nuclear
transcription factor that regulates the system's anti-oxidative stress response. The activation …

Therapeutic effect of the total saponin from Panax Japonicus on experimental autoimmune encephalomyelitis by attenuating inflammation and regulating gut …

J Wang, L He, S Wang, H Zhao, J Chen, Y Dong… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Rhizomes of Panax japonicus (RPJ), a traditional
herbal medicine, was used for treating arthritis and physical weakness in China from the …

Semaglutide, a novel glucagon-like peptide-1 agonist, amends experimental autoimmune encephalomyelitis-induced multiple sclerosis in mice: Involvement of the …

MA Sadek, EA Kandil, NS El Sayed, HM Sayed… - International …, 2023 - Elsevier
Multiple sclerosis (MS) is a disabling neurodegenerative disease that causes demyelination
and axonal degeneration of the central nervous system. Current treatments are partially …

Potential utility of natural products against oxidative stress in animal models of multiple sclerosis

Z Zha, S Liu, Y Liu, C Li, L Wang - Antioxidants, 2022 - mdpi.com
Multiple sclerosis (MS) is an autoimmune-mediated degenerative disease of the central
nervous system (CNS) characterized by immune cell infiltration, demyelination and axonal …

Inhibition of ITK signaling causes amelioration in sepsis-associated neuroinflammation and depression-like state in mice

MM Algahtani, S Alshehri, SS Alqarni… - International Journal of …, 2023 - mdpi.com
Sepsis affects millions of people worldwide and is associated with multiorgan dysfunction
that is a major cause of increased morbidity and mortality. Sepsis is associated with several …

Modulation of p38 MAPK and Nrf2/HO-1/NLRP3 inflammasome signaling and pyroptosis outline the anti-neuroinflammatory and remyelinating characters of …

TK Motawi, SA El-Maraghy, AS Kamel, SE Said… - Biochemical …, 2023 - Elsevier
There is vast evidence for the effect of NOD-like receptor protein-3 (NLRP3) inflammasome
on multiple sclerosis (MS) pathogenesis. Clemastine (CLM) targets NLRP3 in hypoxic brain …

Taurochenodeoxycholic acid reduces astrocytic neuroinflammation and alleviates experimental autoimmune encephalomyelitis in mice

N Xu, Y Bai, X Han, J Yuan, L Wang, Y He, L Yang… - Immunobiology, 2023 - Elsevier
Objective Multiple sclerosis (MS) is an immune regulatory disease that affects the central
nervous system (CNS). The main pathological features include demyelination and …

[PDF][PDF] Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis

C Liu, S Guo, R Liu, M Guo, Q Wang… - Neural Regeneration …, 2023 - journals.lww.com
Multiple sclerosis is characterized by demyelination and neuronal loss caused by
inflammatory cell activation and infiltration into the central nervous system. Macrophage …

Cadmium exposure exacerbates immunological abnormalities in a BTBR T+ Itpr3tf/J autistic mouse model by upregulating inflammatory mediators in CD45R …

TH Albekairi, MM Alanazi, MA Ansari, A Nadeem… - Journal of …, 2024 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental illness characterized by behavior,
learning, communication, and social interaction abnormalities in various situations …