Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical
technique being increasingly applied to a wide variety of problems. As the HDX-MS …

Hydrogen/deuterium exchange (HDX) mass spectrometry (MS) has become a key technique
for monitoring structural and dynamic aspects of proteins in solution. This approach relies on …

Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Noisy and overlapped mass spectrometry data hinder the sequence coverage that can be
obtained from hydrogen deuterium exchange analysis, and places a limit on the complexity …

Assessing the functional outcome of protein interactions in structural terms is a goal of
structural biology, however most techniques have a limited capacity for making structure …

Differential hydrogen exchange-mass spectrometry (HX-MS) measurements are valuable for
identification of differences in the higher order structures of proteins. Typically, the data sets …

Virtually all protein functions in the cell, including pathogenic processes, require coordinated
motion of atoms or domains, ie, conformational dynamics. Understanding protein dynamics …

Hydrogen/Deuterium eXchange Mass Spectrometry (HDX-MS) is a rapidly evolving
technique for analyzing structural features and dynamic properties of proteins. It may stand …

Conventional approaches to site mapping have so far failed to identify the laulimalide
binding site on microtubules. Using mass shift perturbation analysis and data-directed …

Preventing and treating Alzheimer's disease require understanding the aggregation of
amyloid beta 1–42 (Aβ1–42) to give oligomers, protofibrils, and fibrils. Here we describe …