Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

Post-translational acetylation of the core histone amino-terminal tails has long been
associated with both chromatin assembly and the regulation of gene expression. The recent …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

Chromatin disruption and modification are associated with transcriptional regulation by
diverse coactivators and corepressors. Here we discuss the possible structural basis and …

In the mouse embryo, transcriptional activation begins during S/G2 phase of the first cell
cycle when paternal and maternal chromatin are still in separate nuclear entities within the …

The mechanism by which the eukaryotic DNA-replication machinery penetrates condensed
chromatin structures to replicate the underlying DNA is poorly understood. Here we provide …

We characterized the SMC2 (structural maintenance of chromosomes) gene that encodes a
new Saccharomyces cerevisiae member of the growing family of SMC proteins. This family …

Introduction 3. The Stepwise Nature of Genome Activation 4. Changes in Histone Content
Accompanying Genome Activation 4.1. Changes in Histone Protein Expression 4.2 …

Epigenetic mechanisms set apart the active and inactive regions in the genome of
multicellular organisms to produce distinct cell fates during embryogenesis. Here, we report …

In mouse, the oocyte-to-embryo transition entails converting a highly differentiated oocyte to
totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which …