Actinobacteriophages: genomics, dynamics, and applications

GF Hatfull - Annual review of virology, 2020 - annualreviews.org
Actinobacteriophages are viruses that infect bacterial hosts in the phylum Actinobacteria.
More than 17,000 actinobacteriophages have been described and over 3,000 complete …

Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development

N Zhao, Y Song, X Xie, Z Zhu, C Duan… - … and Targeted Therapy, 2023 - nature.com
The fast-developing synthetic biology (SB) has provided many genetic tools to reprogram
and engineer cells for improved performance, novel functions, and diverse applications …

Reporter phage-based detection of bacterial pathogens: design guidelines and recent developments

S Meile, S Kilcher, MJ Loessner, M Dunne - Viruses, 2020 - mdpi.com
Fast and reliable detection of bacterial pathogens in clinical samples, contaminated food
products, and water supplies can drastically improve clinical outcomes and reduce the socio …

Recent progress in the detection of bacteria using bacteriophages: A review

J Paczesny, Ł Richter, R Hołyst - Viruses, 2020 - mdpi.com
Bacteria will likely become our most significant enemies of the 21st century, as we are
approaching a post-antibiotic era. Bacteriophages, viruses that infect bacteria, allow us to …

Mycobacteriophages as potential therapeutic agents against drug-resistant tuberculosis

A Allué-Guardia, R Saranathan, J Chan… - International journal of …, 2021 - mdpi.com
The current emergence of multi-, extensively-, extremely-, and total-drug resistant strains of
Mycobacterium tuberculosis poses a major health, social, and economic threat, and stresses …

The use of bacteriophages in biotechnology and recent insights into proteomics

AG Abril, M Carrera, V Notario, Á Sánchez-Pérez… - Antibiotics, 2022 - mdpi.com
Phages have certain features, such as their ability to form protein–protein interactions, that
make them good candidates for use in a variety of beneficial applications, such as in human …

Engineering Phages to Fight Multidrug-Resistant Bacteria

H Peng, IA Chen, U Qimron - Chemical Reviews, 2024 - ACS Publications
Facing the global “superbug” crisis due to the emergence and selection for antibiotic
resistance, phages are among the most promising solutions. Fighting multidrug-resistant …

Combating infectious diseases with synthetic biology

A Khan, J Ostaku, E Aras… - ACS Synthetic Biology, 2022 - ACS Publications
Over the past decades, there have been numerous outbreaks, including parasitic, fungal,
bacterial, and viral infections, worldwide. The rate at which infectious diseases are emerging …

Feasibility of novel approaches to detect viable Mycobacterium tuberculosis within the spectrum of the tuberculosis disease

S Alebouyeh, B Weinrick, JM Achkar, MJ García… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB) is a global disease caused by Mycobacterium tuberculosis (Mtb) and is
manifested as a continuum spectrum of infectious states. Both, the most common and …

Self-assembled β-galactosidase on T4 phage capsid through affinity binding with enhanced activity and stability for rapid bacteria detection

J Xu, Q Yang, P Wang, D Wu, X Yang, W Chen… - Sensors and Actuators B …, 2022 - Elsevier
Due to the highly efficient and specific catalysis, enzymes have been extensively applied in
various fields. In the development of enzyme-based sensing devices, the immobilization of …