The multifaceted role of TMEM16A in cancer
D Crottès, LY Jan - Cell Calcium, 2019 - Elsevier
The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …
decades, TMEM16A over-expression and contribution to prognosis have been widely …
Lysosomal solute and water transport
Lysosomes mediate hydrolase-catalyzed macromolecule degradation to produce building
block catabolites for reuse. Lysosome function requires an osmo-sensing machinery that …
block catabolites for reuse. Lysosome function requires an osmo-sensing machinery that …
TMEM16A in cystic fibrosis: activating or inhibiting?
K Kunzelmann, J Ousingsawat, I Cabrita… - Frontiers in …, 2019 - frontiersin.org
The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction
due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis …
due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis …
Contribution of anoctamins to cell survival and cell death
K Kunzelmann, J Ousingsawat, R Benedetto, I Cabrita… - Cancers, 2019 - mdpi.com
Before anoctamins (TMEM16 proteins) were identified as a family of Ca2+-activated chloride
channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1 …
channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1 …
Cell volume-activated and volume-correlated anion channels in mammalian cells: their biophysical, molecular, and pharmacological properties
Y Okada, T Okada, K Sato-Numata, MR Islam… - Pharmacological …, 2019 - Elsevier
There are a number of mammalian anion channel types associated with cell volume
changes. These channel types are classified into two groups: volume-activated anion …
changes. These channel types are classified into two groups: volume-activated anion …
Piezo1 controls cell volume and migration by modulating swelling‐activated chloride current through Ca2+ influx
L Sforna, A Michelucci, F Morena… - Journal of Cellular …, 2022 - Wiley Online Library
Regulatory volume decrease (RVD), a homeostatic process responsible for the re‐
establishment of the original cell volume upon swelling, is critical in controlling several …
establishment of the original cell volume upon swelling, is critical in controlling several …
TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1. 1 human airway epithelium
R Centeio, I Cabrita, R Schreiber… - Frontiers in …, 2023 - frontiersin.org
Cl− channels such as the Ca2+ activated Cl− channel TMEM16A and the Cl− permeable
phospholipid scramblase TMEM16F may affect the intracellular Cl− concentration ([Cl−] i) …
phospholipid scramblase TMEM16F may affect the intracellular Cl− concentration ([Cl−] i) …
LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation
The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive
cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is …
cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is …
Comparative effects of chloride channel inhibitors on LRRC8/VRAC-mediated chloride conductance
J Friard, M Tauc, M Cougnon, V Compan… - Frontiers in …, 2017 - frontiersin.org
Chloride channels play an essential role in a variety of physiological functions and in human
diseases. Historically, the field of chloride channels has long been neglected owing to the …
diseases. Historically, the field of chloride channels has long been neglected owing to the …
TMEM16F/anoctamin 6 in ferroptotic cell death
J Ousingsawat, R Schreiber, K Kunzelmann - Cancers, 2019 - mdpi.com
Ca2+ activated Cl− channels (TMEM16A; ANO1) support cell proliferation and cancer
growth. Expression of TMEM16A is strongly enhanced in different types of malignomas. In …
growth. Expression of TMEM16A is strongly enhanced in different types of malignomas. In …