Hippocampal GABAergic inhibitory interneurons

KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research

ML Phillips, HA Swartz - American Journal of Psychiatry, 2014 - Am Psychiatric Assoc
Objective In this critical review, the authors appraise neuroimaging findings in bipolar
disorder in emotion-processing, emotion-regulation, and reward-processing neural circuitry …

Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis

T Wise, J Radua, E Via, N Cardoner, O Abe… - Molecular …, 2017 - nature.com
Finding robust brain substrates of mood disorders is an important target for research. The
degree to which major depression (MDD) and bipolar disorder (BD) are associated with …

Subcortical volumetric abnormalities in bipolar disorder

DP Hibar, LT Westlye, TGM van Erp, J Rasmussen… - Molecular …, 2016 - nature.com
Considerable uncertainty exists about the defining brain changes associated with bipolar
disorder (BD). Understanding and quantifying the sources of uncertainty can help generate …

The impact of environmental factors in severe psychiatric disorders

A Schmitt, B Malchow, A Hasan, P Falkai - Frontiers in neuroscience, 2014 - frontiersin.org
During the last decades, schizophrenia has been regarded as a developmental disorder.
The neurodevelopmental hypothesis proposes schizophrenia to be related to genetic and …

A report on older‐age bipolar disorder from the International Society for Bipolar Disorders Task Force

M Sajatovic, SA Strejilevich, AG Gildengers… - Bipolar …, 2015 - Wiley Online Library
Objectives In the coming generation, older adults with bipolar disorder (BD) will increase in
absolute numbers as well as proportion of the general population. This is the first report of …

Lithium: a review of pharmacology, clinical uses, and toxicity

R Oruch, MA Elderbi, HA Khattab, IF Pryme… - European journal of …, 2014 - Elsevier
A radical drug treatment for bipolar affective disorder (BD) is currently unavailable. This is
attributed to the fact that the precise pathophysiology of this ailment is unclear though a …

Hippocampal subfield volumes in mood disorders

B Cao, IC Passos, B Mwangi, H Amaral-Silva… - Molecular …, 2017 - nature.com
Volume reduction and shape abnormality of the hippocampus have been associated with
mood disorders. However, the hippocampus is not a uniform structure and consists of …

Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders

K Brosch, F Stein, S Schmitt, JK Pfarr… - Molecular …, 2022 - nature.com
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum
disorder (SSD, schizophrenia, and schizoaffective disorder) overlap in symptomatology, risk …

Using structural MRI to identify bipolar disorders–13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group

A Nunes, HG Schnack, CRK Ching, I Agartz… - Molecular …, 2020 - nature.com
Bipolar disorders (BDs) are among the leading causes of morbidity and disability. Objective
biological markers, such as those based on brain imaging, could aid in clinical management …