Non-coding RNAs (ncRNAs) constitute a heterogeneous group of RNA molecules in terms
of biogenesis, biological function as well as length and structure. These biological …

To cope with hypoxic stress, ancient organisms have developed evolutionally conserved
programs centered on hypoxia-inducible transcriptional factors (HIFs). HIFs and their …

Background Acute myeloid leukemia (AML) is a hematological malignancy that remains a
therapeutic challenge due to the high incidence of disease relapse. To better understand …

In chronic lymphocytic leukemia (CLL), the hypoxia-inducible factor 1 (HIF-1) regulates the
response of tumor cells to hypoxia and their protective interactions with the leukemic …

Chronic lymphocytic leukemia (CLL) is one of the most common types of leukemia in adults.
Several studies have identified various prognostic biomarkers in CLL. In this study, we …

MicroRNA‐155‐5p (miR‐155‐5p) is a proinflammatory, oncogenic miRNA, involved in
various physiological processes, including hematopoiesis, immunity, inflammation, and cell …

The use of cisplatin for the treatment of non-small cell lung cancer has long been
constrained by the rapid acquisition of tumor cell chemoresistance. In the present study, we …

Hypoxia-inducible factors (HIFs) were discovered as activators of erythropoietin gene
transcription in response to reduced oxygen (O2) availability. O2-dependent hydroxylation of …

Abstract Objective 3′ tRNA‐derived fragments (3′ tRFs) are important epigenetic
regulators in normal and pathological conditions. In this study, we aimed to explore the …

Abstract MicroRNA-20b-5p (miR-20b-5p) is part of the miR-106a/363 cluster and a member
of the cancer-related miR-17 family. miR-20b-5p regulates important transcription factors …