Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better understanding of the breadth of tumour-associated antigens, the native immune response …
KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
Z Li, Z Chu, J Yang, H Qian, J Xu, B Chen, T Tian… - ACS …, 2022 - ACS Publications
Both T-cell deprivation and insufficient tumor immunogenicity seriously hinder the efficacy of immune-mediated tumor destruction in melanoma. In this work, an amphiphilic polyethylene …
H Zhou, D Tang, Y Yu, L Zhang, B Wang… - Nature …, 2023 - nature.com
Tumor metastases are considered the leading cause of cancer-associated deaths. While clinically applied drugs have demonstrated to efficiently remove the primary tumor …
Z Li, H Cai, Z Li, L Ren, X Ma, H Zhu, Q Gong… - Bioactive materials, 2023 - Elsevier
To improve the response rate of immune checkpoint inhibitors such as anti-PD-L1 antibody in immunosuppressive cancers like triple-negative breast cancer (TNBC), induction of …
Death is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an undesirable but unavoidable final outcome …
Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two major contributors to poor therapeutic responses during cancer intervention. Pyroptosis, a …
Ferroptosis is a programmed cell death pathway discovered in recent years, and ferroptosis‐ inducing agents have great potential as new antitumor candidates. Here, we report a IrIII …
M Zhu, M Yang, J Zhang, Y Yin, X Fan… - Frontiers in …, 2021 - frontiersin.org
Immunogenic cell death (ICD) is a form of regulated cell death (RCD) induced by various stresses and produces antitumor immunity via damage-associated molecular patterns …