Dendritic cell subsets in cancer immunity and tumor antigen sensing

A Del Prete, V Salvi, A Soriani, M Laffranchi… - Cellular & molecular …, 2023 - nature.com
Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …

Therapeutic cancer vaccines

M Saxena, SH van der Burg, CJM Melief… - Nature Reviews …, 2021 - nature.com
Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better
understanding of the breadth of tumour-associated antigens, the native immune response …

Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy

KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Immunogenic cell death augmented by manganese zinc sulfide nanoparticles for metastatic melanoma immunotherapy

Z Li, Z Chu, J Yang, H Qian, J Xu, B Chen, T Tian… - ACS …, 2022 - ACS Publications
Both T-cell deprivation and insufficient tumor immunogenicity seriously hinder the efficacy of
immune-mediated tumor destruction in melanoma. In this work, an amphiphilic polyethylene …

Theranostic imaging and multimodal photodynamic therapy and immunotherapy using the mTOR signaling pathway

H Zhou, D Tang, Y Yu, L Zhang, B Wang… - Nature …, 2023 - nature.com
Tumor metastases are considered the leading cause of cancer-associated deaths. While
clinically applied drugs have demonstrated to efficiently remove the primary tumor …

[HTML][HTML] A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody

Z Li, H Cai, Z Li, L Ren, X Ma, H Zhu, Q Gong… - Bioactive materials, 2023 - Elsevier
To improve the response rate of immune checkpoint inhibitors such as anti-PD-L1 antibody
in immunosuppressive cancers like triple-negative breast cancer (TNBC), induction of …

Diversity and complexity of cell death: a historical review

W Park, S Wei, BS Kim, B Kim, SJ Bae… - … & molecular medicine, 2023 - nature.com
Death is the inevitable fate of all living organisms, whether at the individual or cellular level.
For a long time, cell death was believed to be an undesirable but unavoidable final outcome …

Pyroptosis at the forefront of anticancer immunity

R Loveless, R Bloomquist, Y Teng - Journal of Experimental & Clinical …, 2021 - Springer
Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two
major contributors to poor therapeutic responses during cancer intervention. Pyroptosis, a …

Ferroptosis‐enhanced cancer immunity by a ferrocene‐appended iridium (III) Diphosphine complex

WJ Wang, YY Ling, YM Zhong, ZY Li… - Angewandte Chemie …, 2022 - Wiley Online Library
Ferroptosis is a programmed cell death pathway discovered in recent years, and ferroptosis‐
inducing agents have great potential as new antitumor candidates. Here, we report a IrIII …

Immunogenic cell death induction by ionizing radiation

M Zhu, M Yang, J Zhang, Y Yin, X Fan… - Frontiers in …, 2021 - frontiersin.org
Immunogenic cell death (ICD) is a form of regulated cell death (RCD) induced by various
stresses and produces antitumor immunity via damage-associated molecular patterns …