Blinding and expectancy confounds in psychedelic randomized controlled trials

SD Muthukumaraswamy, A Forsyth… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: There is increasing interest in the potential for psychedelic drugs such as
psilocybin, LSD and ketamine to treat several mental health disorders, with a growing …

Placebo effect in the treatment of depression and anxiety

I Kirsch - Frontiers in Psychiatry, 2019 - frontiersin.org
The aim of this review is to evaluate the placebo effect in the treatment of anxiety and
depression. Antidepressants are supposed to work by fixing a chemical imbalance …

Expectancy in placebo-controlled trials of psychedelics: if so, so what?

M Butler, L Jelen, J Rucker - Psychopharmacology, 2022 - Springer
Modern psychedelic research remains in an early phase, and the eventual introduction of
psychedelics into clinical practice remains in doubt. In this piece, we discuss the role of …

Toward personalized psychotherapy: The importance of the trait-like/state-like distinction for understanding therapeutic change.

S Zilcha-Mano - American Psychologist, 2021 - psycnet.apa.org
For the past hundred years, mechanisms of change have been the black box of
psychotherapy. Thousands of studies failed to produce consistent findings, even concerning …

Biomedical explanations of psychopathology and their implications for attitudes and beliefs about mental disorders

MS Lebowitz, PS Appelbaum - Annual Review of Clinical …, 2019 - annualreviews.org
Mental disorders are increasingly conceptualized as biomedical diseases, explained as
manifestations of genetic and neurobiological abnormalities. Here, we discuss changes in …

Open-label placebo: reflections on a research agenda

TJ Kaptchuk - Perspectives in biology and medicine, 2018 - muse.jhu.edu
Open-label placebos (OLP)—placebo pills honestly prescribed—have challenged the notion
that placebos require either deception or concealment to evoke salubrious benefits. This …

The cognitive neuroscience of placebo effects: concepts, predictions, and physiology

S Geuter, L Koban, TD Wager - Annual review of neuroscience, 2017 - annualreviews.org
Placebos have been used ubiquitously throughout the history of medicine. Expectations and
associative learning processes are important psychological determinants of placebo effects …

Brain mechanisms of the placebo effect: an affective appraisal account

YK Ashar, LJ Chang, TD Wager - Annual review of clinical …, 2017 - annualreviews.org
Placebos are sham medical treatments. Nonetheless, they can have substantial effects on
clinical outcomes. Placebos depend on a person's psychological and brain responses to the …

Probiotics as a treatment for prenatal maternal anxiety and depression: a double-blind randomized pilot trial

PD Browne, AC Bolte, I Besseling-van der Vaart… - Scientific reports, 2021 - nature.com
Probiotic use may be an efficacious treatment option to effectively manage symptoms of
prenatal maternal anxiety and depression. Our primary aim was to test feasibility and …

Thirty years of neuroscientific investigation of placebo and nocebo: the interesting, the good, and the bad

F Benedetti, E Frisaldi, A Shaibani - Annual Review of …, 2022 - annualreviews.org
Over the past 30 years there has been a surge of research on the placebo effect using a
neuroscientific approach. The interesting aspects of this effort are related to the identification …